Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Arnaud Rives, Benjamin Le Calvé, Tamara Delaine, Laurent Legentil, Robert Kiss, Evelyne Delfourne

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

langue originaleAnglais
Pages (de - à)343-51
Nombre de pages9
journalEuropean Journal of Medicinal Chemistry
Volume45
Numéro de publication1
Les DOIs
étatPublié - 2010
Modification externeOui

Empreinte digitale

Pyrroloiminoquinones
Alkaloids
Ethanol
Cells
Cell Line
Neoplasms
In Vitro Techniques

Citer ceci

Rives, Arnaud ; Le Calvé, Benjamin ; Delaine, Tamara ; Legentil, Laurent ; Kiss, Robert ; Delfourne, Evelyne. / Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines. Dans: European Journal of Medicinal Chemistry. 2010 ; Vol 45, Numéro 1. p. 343-51.
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abstract = "Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.",
keywords = "Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Humans, Inhibitory Concentration 50, Oceans and Seas, Quinolines, Journal Article",
author = "Arnaud Rives and {Le Calv{\'e}}, Benjamin and Tamara Delaine and Laurent Legentil and Robert Kiss and Evelyne Delfourne",
note = "Copyright 2009 Elsevier Masson SAS. All rights reserved.",
year = "2010",
doi = "10.1016/j.ejmech.2009.10.019",
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journal = "European journal of medicinal chemistry / Chimica therapeutica",
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Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines. / Rives, Arnaud; Le Calvé, Benjamin; Delaine, Tamara; Legentil, Laurent; Kiss, Robert; Delfourne, Evelyne.

Dans: European Journal of Medicinal Chemistry, Vol 45, Numéro 1, 2010, p. 343-51.

Résultats de recherche: Contribution à un journal/une revueArticle

TY - JOUR

T1 - Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

AU - Rives, Arnaud

AU - Le Calvé, Benjamin

AU - Delaine, Tamara

AU - Legentil, Laurent

AU - Kiss, Robert

AU - Delfourne, Evelyne

N1 - Copyright 2009 Elsevier Masson SAS. All rights reserved.

PY - 2010

Y1 - 2010

N2 - Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

AB - Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Humans

KW - Inhibitory Concentration 50

KW - Oceans and Seas

KW - Quinolines

KW - Journal Article

U2 - 10.1016/j.ejmech.2009.10.019

DO - 10.1016/j.ejmech.2009.10.019

M3 - Article

C2 - 19897281

VL - 45

SP - 343

EP - 351

JO - European journal of medicinal chemistry / Chimica therapeutica

JF - European journal of medicinal chemistry / Chimica therapeutica

SN - 0223-5234

IS - 1

ER -