Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Arnaud Rives; Benjamin Le Calvé; Tamara Delaine; Laurent Legentil; Robert Kiss; Evelyne Delfourne

doi:10.1016/j.ejmech.2009.10.019

Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Arnaud Rives, Benjamin Le Calvé, Tamara Delaine, Laurent Legentil, Robert Kiss, Evelyne Delfourne

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

langue originale	Anglais
Pages (de - à)	343-51
Nombre de pages	9
journal	European Journal of Medicinal Chemistry
Volume	45
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.ejmech.2009.10.019
Etat de la publication	Publié - 2010
Modification externe	Oui

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10.1016/j.ejmech.2009.10.019

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title = "Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines",

abstract = "Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.",

keywords = "Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Humans, Inhibitory Concentration 50, Oceans and Seas, Quinolines, Journal Article",

author = "Arnaud Rives and {Le Calv{\'e}}, Benjamin and Tamara Delaine and Laurent Legentil and Robert Kiss and Evelyne Delfourne",

year = "2010",

doi = "10.1016/j.ejmech.2009.10.019",

language = "English",

volume = "45",

pages = "343--51",

journal = "European Journal of Medicinal Chemistry",

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T1 - Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

AU - Rives, Arnaud

AU - Le Calvé, Benjamin

AU - Delaine, Tamara

AU - Legentil, Laurent

AU - Kiss, Robert

AU - Delfourne, Evelyne

PY - 2010

Y1 - 2010

N2 - Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

AB - Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Humans

KW - Inhibitory Concentration 50

KW - Oceans and Seas

KW - Quinolines

KW - Journal Article

U2 - 10.1016/j.ejmech.2009.10.019

DO - 10.1016/j.ejmech.2009.10.019

M3 - Article

C2 - 19897281

SN - 0223-5234

VL - 45

SP - 343

EP - 351

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 1

ER -

Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

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