Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Arnaud Rives; Benjamin Le Calvé; Tamara Delaine; Laurent Legentil; Robert Kiss; Evelyne Delfourne

doi:10.1016/j.ejmech.2009.10.019

Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Arnaud Rives, Benjamin Le Calvé, Tamara Delaine, Laurent Legentil, Robert Kiss, Evelyne Delfourne

Research output: Contribution to journal › Article › peer-review

Abstract

Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

Original language	English
Pages (from-to)	343-51
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.ejmech.2009.10.019
Publication status	Published - 2010
Externally published	Yes

Keywords

Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Humans
Inhibitory Concentration 50
Oceans and Seas
Quinolines
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2009.10.019

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title = "Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines",

abstract = "Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.",

keywords = "Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Humans, Inhibitory Concentration 50, Oceans and Seas, Quinolines, Journal Article",

author = "Arnaud Rives and {Le Calv{\'e}}, Benjamin and Tamara Delaine and Laurent Legentil and Robert Kiss and Evelyne Delfourne",

year = "2010",

doi = "10.1016/j.ejmech.2009.10.019",

language = "English",

volume = "45",

pages = "343--51",

journal = "European Journal of Medicinal Chemistry",

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TY - JOUR

T1 - Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

AU - Rives, Arnaud

AU - Le Calvé, Benjamin

AU - Delaine, Tamara

AU - Legentil, Laurent

AU - Kiss, Robert

AU - Delfourne, Evelyne

PY - 2010

Y1 - 2010

N2 - Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

AB - Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Humans

KW - Inhibitory Concentration 50

KW - Oceans and Seas

KW - Quinolines

KW - Journal Article

U2 - 10.1016/j.ejmech.2009.10.019

DO - 10.1016/j.ejmech.2009.10.019

M3 - Article

C2 - 19897281

SN - 0223-5234

VL - 45

SP - 343

EP - 351

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 1

ER -

Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Abstract

Keywords

UN SDGs

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