TY - JOUR
T1 - Mechanisms of leukemogenesis induced by bovine leukemia virus
T2 - prospects for novel anti-retroviral therapies in human
AU - Gillet, N.
AU - Florins, A.-F.
AU - Boxus, Mathieu
AU - Burteau, Catherine
AU - Nigro, Annamaria
AU - VANDERMEERS, Fabian
AU - Balon, H.
AU - Bouzar, Amel-Baya
AU - Defoiche, Julien
AU - Burny, Arsène
AU - Reichert, M.
AU - Kettmann, R
AU - Willems, L.
PY - 2007
Y1 - 2007
N2 - In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
AB - In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
KW - Sciences du vivant => Médecine vétérinaire santé animale
KW - Animals
KW - Anti-Retroviral Agents/pharmacology/therapeutic use
KW - B-Lymphocytes/pathology/physiology/virology
KW - Cattle
KW - Cytokines/metabolism
KW - Disease Models, Animal
KW - Enzootic Bovine Leukosis/drug therapy/physiopathology/virology
KW - Human T-lymphotropic virus 1/pathogenicity
KW - Humans
KW - Leukemia Virus, Bovine/genetics/metabolism/pathogenicity
KW - Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology
KW - Leukocytes, Mononuclear/pathology/physiology/virology
KW - Sheep
KW - Sheep Diseases/drug therapy/immunology/physiopathology/virology
KW - Viral Proteins/genetics/metabolism
U2 - 10.1186/1742-4690-4-18
DO - 10.1186/1742-4690-4-18
M3 - Article
VL - 4
SP - 18
JO - Retrovirology
JF - Retrovirology
IS - 1
ER -
