Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

N. Gillet, A.-F. Florins, Mathieu Boxus, Catherine Burteau, Annamaria Nigro, Fabian VANDERMEERS, H. Balon, Amel-Baya Bouzar, Julien Defoiche, Arsène Burny, M. Reichert, R Kettmann, L. Willems

Research output: Contribution to journalArticlepeer-review

Abstract

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
Original languageEnglish
Pages (from-to)18
Number of pages1
JournalRetrovirology
Volume4
Issue number1
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Sciences du vivant => Médecine vétérinaire santé animale
  • Animals
  • Anti-Retroviral Agents/pharmacology/therapeutic use
  • B-Lymphocytes/pathology/physiology/virology
  • Cattle
  • Cytokines/metabolism
  • Disease Models, Animal
  • Enzootic Bovine Leukosis/drug therapy/physiopathology/virology
  • Human T-lymphotropic virus 1/pathogenicity
  • Humans
  • Leukemia Virus, Bovine/genetics/metabolism/pathogenicity
  • Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology
  • Leukocytes, Mononuclear/pathology/physiology/virology
  • Sheep
  • Sheep Diseases/drug therapy/immunology/physiopathology/virology
  • Viral Proteins/genetics/metabolism

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