Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

N. Gillet; A.-F. Florins; Mathieu Boxus; Catherine Burteau; Annamaria Nigro; Fabian VANDERMEERS; H. Balon; Amel-Baya Bouzar; Julien Defoiche; Arsène Burny; M. Reichert; R Kettmann; L. Willems

doi:10.1186/1742-4690-4-18

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

N. Gillet, A.-F. Florins, Mathieu Boxus, Catherine Burteau, Annamaria Nigro, Fabian VANDERMEERS, H. Balon, Amel-Baya Bouzar, Julien Defoiche, Arsène Burny, M. Reichert, R Kettmann, L. Willems

Research output: Contribution to journal › Article › peer-review

Abstract

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.

Original language	English
Pages (from-to)	18
Number of pages	1
Journal	Retrovirology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/1742-4690-4-18
Publication status	Published - 2007
Externally published	Yes

Keywords

Sciences du vivant => Médecine vétérinaire santé animale
Animals
Anti-Retroviral Agents/pharmacology/therapeutic use
B-Lymphocytes/pathology/physiology/virology
Cattle
Cytokines/metabolism
Disease Models, Animal
Enzootic Bovine Leukosis/drug therapy/physiopathology/virology
Human T-lymphotropic virus 1/pathogenicity
Humans
Leukemia Virus, Bovine/genetics/metabolism/pathogenicity
Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology
Leukocytes, Mononuclear/pathology/physiology/virology
Sheep
Sheep Diseases/drug therapy/immunology/physiopathology/virology
Viral Proteins/genetics/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1742-4690-4-18

http://hdl.handle.net/2268/10555; http://hdl.handle.net/2268/32022

Cite this

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title = "Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human",

abstract = "In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.",

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author = "N. Gillet and A.-F. Florins and Mathieu Boxus and Catherine Burteau and Annamaria Nigro and Fabian VANDERMEERS and H. Balon and Amel-Baya Bouzar and Julien Defoiche and Ars{\`e}ne Burny and M. Reichert and R Kettmann and L. Willems",

year = "2007",

doi = "10.1186/1742-4690-4-18",

language = "English",

volume = "4",

pages = "18",

journal = "Retrovirology",

publisher = "BioMed Central",

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TY - JOUR

T1 - Mechanisms of leukemogenesis induced by bovine leukemia virus

T2 - prospects for novel anti-retroviral therapies in human

AU - Gillet, N.

AU - Florins, A.-F.

AU - Boxus, Mathieu

AU - Burteau, Catherine

AU - Nigro, Annamaria

AU - VANDERMEERS, Fabian

AU - Balon, H.

AU - Bouzar, Amel-Baya

AU - Defoiche, Julien

AU - Burny, Arsène

AU - Reichert, M.

AU - Kettmann, R

AU - Willems, L.

PY - 2007

Y1 - 2007

N2 - In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.

AB - In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.

KW - Sciences du vivant => Médecine vétérinaire santé animale

KW - Animals

KW - Anti-Retroviral Agents/pharmacology/therapeutic use

KW - B-Lymphocytes/pathology/physiology/virology

KW - Cattle

KW - Cytokines/metabolism

KW - Disease Models, Animal

KW - Enzootic Bovine Leukosis/drug therapy/physiopathology/virology

KW - Human T-lymphotropic virus 1/pathogenicity

KW - Humans

KW - Leukemia Virus, Bovine/genetics/metabolism/pathogenicity

KW - Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology

KW - Leukocytes, Mononuclear/pathology/physiology/virology

KW - Sheep

KW - Sheep Diseases/drug therapy/immunology/physiopathology/virology

KW - Viral Proteins/genetics/metabolism

U2 - 10.1186/1742-4690-4-18

DO - 10.1186/1742-4690-4-18

M3 - Article

VL - 4

SP - 18

JO - Retrovirology

JF - Retrovirology

IS - 1

ER -

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

Abstract

Keywords

UN SDGs

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