Gold nanoparticles meet medical radionuclides

Noami Daems, Carine Michiels, Stéphane Lucas, Sarah Baatout, An Aerts

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

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Thanks to their unique optical and physicochemical properties, gold nanoparticles have gained increased interest as radiosensitizing, photothermal therapy and optical imaging agents to enhance the effectiveness of cancer detection and therapy. Furthermore, their ability to carry multiple medically relevant radionuclides broadens their use to nuclear medicine SPECT and PET imaging as well as targeted radionuclide therapy. In this review, we discuss the radiolabeling process of gold nanoparticles and their use in (multimodal) nuclear medicine imaging to better understand their specific distribution, uptake and retention in different in vivo cancer models. In addition, radiolabeled gold nanoparticles enable image-guided therapy is reviewed as well as the enhancement of targeted radionuclide therapy and nanobrachytherapy through an increased dose deposition and radiosensitization, as demonstrated by multiple Monte Carlo studies and experimental in vitro and in vivo studies.

langue originaleAnglais
Pages (de - à)61-90
Nombre de pages30
journalNuclear Medicine and Biology
Date de mise en ligne précoce2021
Les DOIs
Etat de la publicationPublié - 1 sept. 2021

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