Gold nanoparticles meet medical radionuclides

Noami Daems, Carine Michiels, Stéphane Lucas, Sarah Baatout, An Aerts

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Abstract

Thanks to their unique optical and physicochemical properties, gold nanoparticles have gained increased interest as radiosensitizing, photothermal therapy and optical imaging agents to enhance the effectiveness of cancer detection and therapy. Furthermore, their ability to carry multiple medically relevant radionuclides broadens their use to nuclear medicine SPECT and PET imaging as well as targeted radionuclide therapy. In this review, we discuss the radiolabeling process of gold nanoparticles and their use in (multimodal) nuclear medicine imaging to better understand their specific distribution, uptake and retention in different in vivo cancer models. In addition, radiolabeled gold nanoparticles enable image-guided therapy is reviewed as well as the enhancement of targeted radionuclide therapy and nanobrachytherapy through an increased dose deposition and radiosensitization, as demonstrated by multiple Monte Carlo studies and experimental in vitro and in vivo studies.

Original languageEnglish
Pages (from-to)61-90
Number of pages30
JournalNuclear Medicine and Biology
Volume100-101
Early online date2021
DOIs
Publication statusPublished - 1 Sept 2021

Keywords

  • Cancer theranostics
  • Dose enhancement
  • Nanobrachytherapy
  • Nuclear medicine
  • Radiosensitization
  • Targeted radionuclide therapy

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