Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity

André Gergs, Devdutt Kulkarni, Thomas G. Preuss

Résultats de recherche: Contribution à un journal/une revueArticle

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Résumé

Ecological risk assessment of chemicals aims at quantifying the likelihood of adverse effects posed to non-target populations and the communities they constitute, often based on lethal concentration estimates for standard test species. There may, however, be intra- and interspecific differences in responses to chemical exposure. Here with the help of a toxicokinetic-toxicodynamic model, we explored whether differential body sizes might explain the observed variability in sensitivity between species and between life-stages of each individual species, for three model organisms, Daphnia magna, Chaoborus crystallinus and Mesocyclops leuckarti. While body size-dependent toxicokinetics could be used to predict intraspecies variation in sensitivity, our results also suggest that changes in both toxicokinetic and toxicodynamic parameters might be needed to describe differential species sensitivity. Accounting for biological traits, like body size, in mechanistic effect models will allow more accurate predictions of chemical effects in size structured populations, ultimately providing mechanistic explanations for species sensitivity distributions.

langue originaleAnglais
Pages (de - à)449-455
Nombre de pages7
journalEnvironmental Pollution
Volume206
Les DOIs
étatPublié - 14 août 2015

Empreinte digitale

Body Size
Risk assessment
Daphnia
Copepoda
Population Density
Population
Toxicokinetics

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abstract = "Ecological risk assessment of chemicals aims at quantifying the likelihood of adverse effects posed to non-target populations and the communities they constitute, often based on lethal concentration estimates for standard test species. There may, however, be intra- and interspecific differences in responses to chemical exposure. Here with the help of a toxicokinetic-toxicodynamic model, we explored whether differential body sizes might explain the observed variability in sensitivity between species and between life-stages of each individual species, for three model organisms, Daphnia magna, Chaoborus crystallinus and Mesocyclops leuckarti. While body size-dependent toxicokinetics could be used to predict intraspecies variation in sensitivity, our results also suggest that changes in both toxicokinetic and toxicodynamic parameters might be needed to describe differential species sensitivity. Accounting for biological traits, like body size, in mechanistic effect models will allow more accurate predictions of chemical effects in size structured populations, ultimately providing mechanistic explanations for species sensitivity distributions.",
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Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity. / Gergs, André; Kulkarni, Devdutt; Preuss, Thomas G.

Dans: Environmental Pollution, Vol 206, 14.08.2015, p. 449-455.

Résultats de recherche: Contribution à un journal/une revueArticle

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AU - Kulkarni, Devdutt

AU - Preuss, Thomas G.

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KW - General unified threshold model of survival (GUTS)

KW - Species sensitivity

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