Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity

André Gergs, Devdutt Kulkarni, Thomas G. Preuss

Research output: Contribution to journalArticle

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Abstract

Ecological risk assessment of chemicals aims at quantifying the likelihood of adverse effects posed to non-target populations and the communities they constitute, often based on lethal concentration estimates for standard test species. There may, however, be intra- and interspecific differences in responses to chemical exposure. Here with the help of a toxicokinetic-toxicodynamic model, we explored whether differential body sizes might explain the observed variability in sensitivity between species and between life-stages of each individual species, for three model organisms, Daphnia magna, Chaoborus crystallinus and Mesocyclops leuckarti. While body size-dependent toxicokinetics could be used to predict intraspecies variation in sensitivity, our results also suggest that changes in both toxicokinetic and toxicodynamic parameters might be needed to describe differential species sensitivity. Accounting for biological traits, like body size, in mechanistic effect models will allow more accurate predictions of chemical effects in size structured populations, ultimately providing mechanistic explanations for species sensitivity distributions.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalEnvironmental Pollution
Volume206
DOIs
Publication statusPublished - 14 Aug 2015

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Body Size
Risk assessment
Daphnia
Copepoda
Population Density
Population
Toxicokinetics

Keywords

  • Body size
  • General unified threshold model of survival (GUTS)
  • Species sensitivity
  • Toxicokinetic-toxicodynamic (TK-TD) model

Cite this

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abstract = "Ecological risk assessment of chemicals aims at quantifying the likelihood of adverse effects posed to non-target populations and the communities they constitute, often based on lethal concentration estimates for standard test species. There may, however, be intra- and interspecific differences in responses to chemical exposure. Here with the help of a toxicokinetic-toxicodynamic model, we explored whether differential body sizes might explain the observed variability in sensitivity between species and between life-stages of each individual species, for three model organisms, Daphnia magna, Chaoborus crystallinus and Mesocyclops leuckarti. While body size-dependent toxicokinetics could be used to predict intraspecies variation in sensitivity, our results also suggest that changes in both toxicokinetic and toxicodynamic parameters might be needed to describe differential species sensitivity. Accounting for biological traits, like body size, in mechanistic effect models will allow more accurate predictions of chemical effects in size structured populations, ultimately providing mechanistic explanations for species sensitivity distributions.",
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Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity. / Gergs, André; Kulkarni, Devdutt; Preuss, Thomas G.

In: Environmental Pollution, Vol. 206, 14.08.2015, p. 449-455.

Research output: Contribution to journalArticle

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