Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L.

Le Thi Bach; Le Tien Dung; Nguyen Trong Tuan; Nguyen Thanh Phuong; Patrick Kestemont; Joëlle Quetin-Leclercq; Bui Thi Buu Hue

doi:10.1063/1.5082519

Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L.

Le Thi Bach, Le Tien Dung, Nguyen Trong Tuan, Nguyen Thanh Phuong, Patrick Kestemont, Joëlle Quetin-Leclercq, Bui Thi Buu Hue

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Résumé

Euphorbia hirta L. has been proved a medicinally important plant. This study aimed to investigate the antioxidant capacities of fractioned extracts and some isolated compounds from Euphorbia hirta L. on pancreatic β-cells MIN6 exposed to hydrogen peroxide-oxidative stress conditions. Four pure compounds were isolated from ethyl acetate and methanol extracts and identified as quercitrin (1), luteolin (2), quercetin (3) and caffeic acid (4). The results showed that the ethyl acetate extract as well as quercetin possess strong protective effects with the cell viability of 81% and 82% at the dose of 0.1 mg/mL. This proves that E hirta L. is a potentially natural antioxidative plant and worth testing for further pharmacological potential in the treatment of oxidative stress which may be related to neurodegenerative diseases.

langue originale	Anglais
titre	3rd International Seminar on Chemistry
Sous-titre	Green Chemistry and Its Role for Sustainability
rédacteurs en chef	Fredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
Editeur	American institute of physics
ISBN (Electronique)	9780735417755
Les DOIs	https://doi.org/10.1063/1.5082519
Etat de la publication	Publié - 14 déc. 2018
Evénement	3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonésie Durée: 18 juil. 2018 → 19 juil. 2018

Série de publications

Nom	AIP Conference Proceedings
Volume	2049
ISSN (imprimé)	0094-243X
ISSN (Electronique)	1551-7616

Une conférence

Une conférence	3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
Pays/Territoire	Indonésie
La ville	Surabaya
période	18/07/18 → 19/07/18

SDG des Nations Unies

Ce résultat contribue à ou aux Objectifs de développement durable suivants

Accès au document

10.1063/1.5082519

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Bach, L. T., Dung, L. T., Tuan, N. T., Phuong, N. T., Kestemont, P., Quetin-Leclercq, J., & Hue, B. T. B. (2018). Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L. Dans F. Kurniawan, Y. Kusumawati, S. Fatmawati, H. Juwono, & A. S. Purnomo (eds.), 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability Article 030018 (AIP Conference Proceedings; Vol 2049). American institute of physics. https://doi.org/10.1063/1.5082519

Bach, Le Thi ; Dung, Le Tien ; Tuan, Nguyen Trong et al. / Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L. 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. Editeur / Fredy Kurniawan ; Yuly Kusumawati ; Sri Fatmawati ; Hendro Juwono ; Adi Setyo Purnomo. American institute of physics, 2018. (AIP Conference Proceedings).

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title = "Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L.",

abstract = "Euphorbia hirta L. has been proved a medicinally important plant. This study aimed to investigate the antioxidant capacities of fractioned extracts and some isolated compounds from Euphorbia hirta L. on pancreatic β-cells MIN6 exposed to hydrogen peroxide-oxidative stress conditions. Four pure compounds were isolated from ethyl acetate and methanol extracts and identified as quercitrin (1), luteolin (2), quercetin (3) and caffeic acid (4). The results showed that the ethyl acetate extract as well as quercetin possess strong protective effects with the cell viability of 81% and 82% at the dose of 0.1 mg/mL. This proves that E hirta L. is a potentially natural antioxidative plant and worth testing for further pharmacological potential in the treatment of oxidative stress which may be related to neurodegenerative diseases.",

keywords = "antioxiant activity, Euphorbia hirta L., MIN6",

author = "Bach, {Le Thi} and Dung, {Le Tien} and Tuan, {Nguyen Trong} and Phuong, {Nguyen Thanh} and Patrick Kestemont and Jo{\"e}lle Quetin-Leclercq and Hue, {Bui Thi Buu}",

year = "2018",

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doi = "10.1063/1.5082519",

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Bach, LT, Dung, LT, Tuan, NT, Phuong, NT, Kestemont, P, Quetin-Leclercq, J & Hue, BTB 2018, Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L. Dans F Kurniawan, Y Kusumawati, S Fatmawati, H Juwono & AS Purnomo (eds), 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability., 030018, AIP Conference Proceedings, VOL. 2049, American institute of physics, 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018, Surabaya, Indonésie, 18/07/18. https://doi.org/10.1063/1.5082519

Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L. / Bach, Le Thi; Dung, Le Tien; Tuan, Nguyen Trong et al.
3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. Ed. / Fredy Kurniawan; Yuly Kusumawati; Sri Fatmawati; Hendro Juwono; Adi Setyo Purnomo. American institute of physics, 2018. 030018 (AIP Conference Proceedings; Vol 2049).

Résultats de recherche: Contribution dans un livre/un catalogue/un rapport/dans les actes d'une conférence › Article dans les actes d'une conférence/un colloque

TY - GEN

T1 - Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L.

AU - Bach, Le Thi

AU - Dung, Le Tien

AU - Tuan, Nguyen Trong

AU - Phuong, Nguyen Thanh

AU - Kestemont, Patrick

AU - Quetin-Leclercq, Joëlle

AU - Hue, Bui Thi Buu

PY - 2018/12/14

Y1 - 2018/12/14

N2 - Euphorbia hirta L. has been proved a medicinally important plant. This study aimed to investigate the antioxidant capacities of fractioned extracts and some isolated compounds from Euphorbia hirta L. on pancreatic β-cells MIN6 exposed to hydrogen peroxide-oxidative stress conditions. Four pure compounds were isolated from ethyl acetate and methanol extracts and identified as quercitrin (1), luteolin (2), quercetin (3) and caffeic acid (4). The results showed that the ethyl acetate extract as well as quercetin possess strong protective effects with the cell viability of 81% and 82% at the dose of 0.1 mg/mL. This proves that E hirta L. is a potentially natural antioxidative plant and worth testing for further pharmacological potential in the treatment of oxidative stress which may be related to neurodegenerative diseases.

AB - Euphorbia hirta L. has been proved a medicinally important plant. This study aimed to investigate the antioxidant capacities of fractioned extracts and some isolated compounds from Euphorbia hirta L. on pancreatic β-cells MIN6 exposed to hydrogen peroxide-oxidative stress conditions. Four pure compounds were isolated from ethyl acetate and methanol extracts and identified as quercitrin (1), luteolin (2), quercetin (3) and caffeic acid (4). The results showed that the ethyl acetate extract as well as quercetin possess strong protective effects with the cell viability of 81% and 82% at the dose of 0.1 mg/mL. This proves that E hirta L. is a potentially natural antioxidative plant and worth testing for further pharmacological potential in the treatment of oxidative stress which may be related to neurodegenerative diseases.

KW - antioxiant activity

KW - Euphorbia hirta L.

KW - MIN6

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U2 - 10.1063/1.5082519

DO - 10.1063/1.5082519

M3 - Conference contribution

AN - SCOPUS:85058996769

T3 - AIP Conference Proceedings

BT - 3rd International Seminar on Chemistry

A2 - Kurniawan, Fredy

A2 - Kusumawati, Yuly

A2 - Fatmawati, Sri

A2 - Juwono, Hendro

A2 - Purnomo, Adi Setyo

PB - American institute of physics

T2 - 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018

Y2 - 18 July 2018 through 19 July 2018

ER -

Bach LT, Dung LT, Tuan NT, Phuong NT, Kestemont P, Quetin-Leclercq J et al. Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L. Dans Kurniawan F, Kusumawati Y, Fatmawati S, Juwono H, Purnomo AS, rédacteurs en chef, 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. American institute of physics. 2018. 030018. (AIP Conference Proceedings). doi: 10.1063/1.5082519

Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L.

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SDG des Nations Unies

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