Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L.

Le Thi Bach, Le Tien Dung, Nguyen Trong Tuan, Nguyen Thanh Phuong, Patrick Kestemont, Joëlle Quetin-Leclercq, Bui Thi Buu Hue

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Résumé

Euphorbia hirta L. has been proved a medicinally important plant. This study aimed to investigate the antioxidant capacities of fractioned extracts and some isolated compounds from Euphorbia hirta L. on pancreatic β-cells MIN6 exposed to hydrogen peroxide-oxidative stress conditions. Four pure compounds were isolated from ethyl acetate and methanol extracts and identified as quercitrin (1), luteolin (2), quercetin (3) and caffeic acid (4). The results showed that the ethyl acetate extract as well as quercetin possess strong protective effects with the cell viability of 81% and 82% at the dose of 0.1 mg/mL. This proves that E hirta L. is a potentially natural antioxidative plant and worth testing for further pharmacological potential in the treatment of oxidative stress which may be related to neurodegenerative diseases.

langue originaleAnglais
titre3rd International Seminar on Chemistry
Sous-titreGreen Chemistry and Its Role for Sustainability
rédacteurs en chefFredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
EditeurAmerican institute of physics
ISBN (Electronique)9780735417755
Les DOIs
étatPublié - 14 déc. 2018
Evénement3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonésie
Durée: 18 juil. 201819 juil. 2018

Série de publications

NomAIP Conference Proceedings
Volume2049
ISSN (imprimé)0094-243X
ISSN (Electronique)1551-7616

Une conférence

Une conférence3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
PaysIndonésie
La villeSurabaya
période18/07/1819/07/18

    Empreinte digitale

Contient cette citation

Bach, L. T., Dung, L. T., Tuan, N. T., Phuong, N. T., Kestemont, P., Quetin-Leclercq, J., & Hue, B. T. B. (2018). Antioxidant activity against hydrogen peroxide-induced cytotoxicity of Euphorbia hirta L. Dans F. Kurniawan, Y. Kusumawati, S. Fatmawati, H. Juwono, & A. S. Purnomo (eds.), 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability [030018] (AIP Conference Proceedings; Vol 2049). American institute of physics. https://doi.org/10.1063/1.5082519