Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

Marko Topalovic; Eric Derom; Christian R. Osadnik; Thierry Troosters; Marc Decramer; Wim Janssens; R. Vanherreweghe; R. Deman; S. Deryke; B. Ghesyens; M. Haerens; S. Maddens; W. Bultynck; W. Temmerman; L. Van Zandweghe; R. De Pauw; C. Depuydt; C. Haenebalcke; V. Ringoet; D. Van Renterghem; An Carlier; D. Colle; C. De Cock; J. Lamont; P. Brancaleone; M. Vander Stappen; R. Peché; Annick Pierard; P. Quarré; Alain Van Meerhaeghe; Didier Cataldo; J. L. Corhay; B. Duysinx; V. Heinen; M. Naldi; D. Nguyen; L. Renaud; M. Cotils; P. Duchatelet; A. Gocmen; C. Lenclud; Philippe Lebrun; J. Noel; A. Frémault; Patrick Bertrand; B. Bouckaert; I. Demedts; P. Demuynck; E. Frans; E. Marchand; on behalf of the Belgian Pulmonary Function Study Investigators

doi:10.1186/s12931-015-0252-0

Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

Marko Topalovic, Eric Derom, Christian R. Osadnik, Thierry Troosters, Marc Decramer, Wim Janssens, R. Vanherreweghe, R. Deman, S. Deryke, B. Ghesyens, M. Haerens, S. Maddens, W. Bultynck, W. Temmerman, L. Van Zandweghe, R. De Pauw, C. Depuydt, C. Haenebalcke, V. Ringoet, D. Van RenterghemAn Carlier, D. Colle, C. De Cock, J. Lamont, P. Brancaleone, M. Vander Stappen, R. Peché, Annick Pierard, P. Quarré, Alain Van Meerhaeghe, Didier Cataldo, J. L. Corhay, B. Duysinx, V. Heinen, M. Naldi, D. Nguyen, L. Renaud, M. Cotils, P. Duchatelet, A. Gocmen, C. Lenclud, Philippe Lebrun, J. Noel, A. Frémault, Patrick Bertrand, B. Bouckaert, I. Demedts, P. Demuynck, E. Frans, E. Marchand, on behalf of the Belgian Pulmonary Function Study Investigators

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Background: Airway resistance (R_AW) and specific airway conductance (sG_AW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of R_AW and sG_AW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: R_AW and sG_AW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal R_AW and sG_AW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sG_AW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, R_AW was found to be more relevant and statistically significant. In asthma patients with normal FEV₁/FVC ratio, both R_AW and sG_AW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: R_AW and sG_AW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

langue originale	Anglais
Numéro d'article	88
journal	Respiratory Research
Volume	16
Numéro de publication	1
Les DOIs	https://doi.org/10.1186/s12931-015-0252-0
Etat de la publication	Publié - 22 juil. 2015
Modification externe	Oui

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10.1186/s12931-015-0252-0

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Topalovic, M., Derom, E., Osadnik, C. R., Troosters, T., Decramer, M., Janssens, W., Vanherreweghe, R., Deman, R., Deryke, S., Ghesyens, B., Haerens, M., Maddens, S., Bultynck, W., Temmerman, W., Van Zandweghe, L., De Pauw, R., Depuydt, C., Haenebalcke, C., Ringoet, V., ... on behalf of the Belgian Pulmonary Function Study Investigators (2015). Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. Respiratory Research, 16(1), Article 88. https://doi.org/10.1186/s12931-015-0252-0

@article{4a39a143239f458f9f0aa7700c99b60c,

title = "Airways resistance and specific conductance for the diagnosis of obstructive airways diseases",

abstract = "Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.",

keywords = "Airway resistance, Asthma, Body-plethysmography, Chronic obstructive pulmonary disease, Pulmonary function tests",

author = "Marko Topalovic and Eric Derom and Osadnik, {Christian R.} and Thierry Troosters and Marc Decramer and Wim Janssens and R. Vanherreweghe and R. Deman and S. Deryke and B. Ghesyens and M. Haerens and S. Maddens and W. Bultynck and W. Temmerman and {Van Zandweghe}, L. and {De Pauw}, R. and C. Depuydt and C. Haenebalcke and V. Ringoet and {Van Renterghem}, D. and An Carlier and D. Colle and {De Cock}, C. and J. Lamont and P. Brancaleone and {Vander Stappen}, M. and R. Pech{\'e} and Annick Pierard and P. Quarr{\'e} and {Van Meerhaeghe}, Alain and Didier Cataldo and Corhay, {J. L.} and B. Duysinx and V. Heinen and M. Naldi and D. Nguyen and L. Renaud and M. Cotils and P. Duchatelet and A. Gocmen and C. Lenclud and Philippe Lebrun and J. Noel and A. Fr{\'e}mault and Patrick Bertrand and B. Bouckaert and I. Demedts and P. Demuynck and E. Frans and E. Marchand and {on behalf of the Belgian Pulmonary Function Study Investigators}",

year = "2015",

month = jul,

day = "22",

doi = "10.1186/s12931-015-0252-0",

language = "English",

volume = "16",

journal = "Respiratory Research",

issn = "1465-9921",

publisher = "BioMed Central",

number = "1",

}

Topalovic, M, Derom, E, Osadnik, CR, Troosters, T, Decramer, M, Janssens, W, Vanherreweghe, R, Deman, R, Deryke, S, Ghesyens, B, Haerens, M, Maddens, S, Bultynck, W, Temmerman, W, Van Zandweghe, L, De Pauw, R, Depuydt, C, Haenebalcke, C, Ringoet, V, Van Renterghem, D, Carlier, A, Colle, D, De Cock, C, Lamont, J, Brancaleone, P, Vander Stappen, M, Peché, R, Pierard, A, Quarré, P, Van Meerhaeghe, A, Cataldo, D, Corhay, JL, Duysinx, B, Heinen, V, Naldi, M, Nguyen, D, Renaud, L, Cotils, M, Duchatelet, P, Gocmen, A, Lenclud, C, Lebrun, P, Noel, J, Frémault, A, Bertrand, P, Bouckaert, B, Demedts, I, Demuynck, P, Frans, E, Marchand, E & on behalf of the Belgian Pulmonary Function Study Investigators 2015, 'Airways resistance and specific conductance for the diagnosis of obstructive airways diseases', Respiratory Research, VOL. 16, Numéro 1, 88. https://doi.org/10.1186/s12931-015-0252-0

TY - JOUR

T1 - Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

AU - Topalovic, Marko

AU - Derom, Eric

AU - Osadnik, Christian R.

AU - Troosters, Thierry

AU - Decramer, Marc

AU - Janssens, Wim

AU - Vanherreweghe, R.

AU - Deman, R.

AU - Deryke, S.

AU - Ghesyens, B.

AU - Haerens, M.

AU - Maddens, S.

AU - Bultynck, W.

AU - Temmerman, W.

AU - Van Zandweghe, L.

AU - De Pauw, R.

AU - Depuydt, C.

AU - Haenebalcke, C.

AU - Ringoet, V.

AU - Van Renterghem, D.

AU - Carlier, An

AU - Colle, D.

AU - De Cock, C.

AU - Lamont, J.

AU - Brancaleone, P.

AU - Vander Stappen, M.

AU - Peché, R.

AU - Pierard, Annick

AU - Quarré, P.

AU - Van Meerhaeghe, Alain

AU - Cataldo, Didier

AU - Corhay, J. L.

AU - Duysinx, B.

AU - Heinen, V.

AU - Naldi, M.

AU - Nguyen, D.

AU - Renaud, L.

AU - Cotils, M.

AU - Duchatelet, P.

AU - Gocmen, A.

AU - Lenclud, C.

AU - Lebrun, Philippe

AU - Noel, J.

AU - Frémault, A.

AU - Bertrand, Patrick

AU - Bouckaert, B.

AU - Demedts, I.

AU - Demuynck, P.

AU - Frans, E.

AU - Marchand, E.

AU - on behalf of the Belgian Pulmonary Function Study Investigators

PY - 2015/7/22

Y1 - 2015/7/22

N2 - Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

AB - Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

KW - Airway resistance

KW - Asthma

KW - Body-plethysmography

KW - Chronic obstructive pulmonary disease

KW - Pulmonary function tests

UR - http://www.scopus.com/inward/record.url?scp=84937250253&partnerID=8YFLogxK

U2 - 10.1186/s12931-015-0252-0

DO - 10.1186/s12931-015-0252-0

M3 - Article

AN - SCOPUS:84937250253

SN - 1465-9921

VL - 16

JO - Respiratory Research

JF - Respiratory Research

IS - 1

M1 - 88

ER -

Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

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