Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

Marko Topalovic, Eric Derom, Christian R. Osadnik, Thierry Troosters, Marc Decramer, Wim Janssens, R. Vanherreweghe, R. Deman, S. Deryke, B. Ghesyens, M. Haerens, S. Maddens, W. Bultynck, W. Temmerman, L. Van Zandweghe, R. De Pauw, C. Depuydt, C. Haenebalcke, V. Ringoet, D. Van Renterghem & 31 Autres An Carlier, D. Colle, C. De Cock, J. Lamont, P. Brancaleone, M. Vander Stappen, R. Peché, Annick Pierard, P. Quarré, Alain Van Meerhaeghe, Didier Cataldo, J. L. Corhay, B. Duysinx, V. Heinen, M. Naldi, D. Nguyen, L. Renaud, M. Cotils, P. Duchatelet, A. Gocmen, C. Lenclud, Philippe Lebrun, J. Noel, A. Frémault, Patrick Bertrand, B. Bouckaert, I. Demedts, P. Demuynck, E. Frans, E. Marchand, on behalf of the Belgian Pulmonary Function Study Investigators

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

langueAnglais
Numéro d'article88
journalRespiratory Research
Volume16
Numéro1
Les DOIs
étatPublié - 22 juil. 2015
Modification externeOui

Empreinte digitale

Airway Resistance
Asthma
Chronic Obstructive Pulmonary Disease
Belgium
Respiratory Function Tests
Airway Obstruction
Routine Diagnostic Tests
Lung Diseases
Healthy Volunteers
Physicians
Lung
Population

mots-clés

    Citer ceci

    Topalovic, M., Derom, E., Osadnik, C. R., Troosters, T., Decramer, M., Janssens, W., ... on behalf of the Belgian Pulmonary Function Study Investigators (2015). Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. DOI: 10.1186/s12931-015-0252-0
    Topalovic, Marko ; Derom, Eric ; Osadnik, Christian R. ; Troosters, Thierry ; Decramer, Marc ; Janssens, Wim ; Vanherreweghe, R. ; Deman, R. ; Deryke, S. ; Ghesyens, B. ; Haerens, M. ; Maddens, S. ; Bultynck, W. ; Temmerman, W. ; Van Zandweghe, L. ; De Pauw, R. ; Depuydt, C. ; Haenebalcke, C. ; Ringoet, V. ; Van Renterghem, D. ; Carlier, An ; Colle, D. ; De Cock, C. ; Lamont, J. ; Brancaleone, P. ; Vander Stappen, M. ; Peché, R. ; Pierard, Annick ; Quarré, P. ; Van Meerhaeghe, Alain ; Cataldo, Didier ; Corhay, J. L. ; Duysinx, B. ; Heinen, V. ; Naldi, M. ; Nguyen, D. ; Renaud, L. ; Cotils, M. ; Duchatelet, P. ; Gocmen, A. ; Lenclud, C. ; Lebrun, Philippe ; Noel, J. ; Frémault, A. ; Bertrand, Patrick ; Bouckaert, B. ; Demedts, I. ; Demuynck, P. ; Frans, E. ; Marchand, E. ; on behalf of the Belgian Pulmonary Function Study Investigators. / Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. Dans: Respiratory Research. 2015 ; Vol 16, Numéro 1.
    @article{4a39a143239f458f9f0aa7700c99b60c,
    title = "Airways resistance and specific conductance for the diagnosis of obstructive airways diseases",
    abstract = "Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 {\%} and 18 {\%} of the population, respectively, in which 81 {\%} and 90 {\%} had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.",
    keywords = "Airway resistance, Asthma, Body-plethysmography, Chronic obstructive pulmonary disease, Pulmonary function tests",
    author = "Marko Topalovic and Eric Derom and Osadnik, {Christian R.} and Thierry Troosters and Marc Decramer and Wim Janssens and R. Vanherreweghe and R. Deman and S. Deryke and B. Ghesyens and M. Haerens and S. Maddens and W. Bultynck and W. Temmerman and {Van Zandweghe}, L. and {De Pauw}, R. and C. Depuydt and C. Haenebalcke and V. Ringoet and {Van Renterghem}, D. and An Carlier and D. Colle and {De Cock}, C. and J. Lamont and P. Brancaleone and {Vander Stappen}, M. and R. Pech{\'e} and Annick Pierard and P. Quarr{\'e} and {Van Meerhaeghe}, Alain and Didier Cataldo and Corhay, {J. L.} and B. Duysinx and V. Heinen and M. Naldi and D. Nguyen and L. Renaud and M. Cotils and P. Duchatelet and A. Gocmen and C. Lenclud and Philippe Lebrun and J. Noel and A. Fr{\'e}mault and Patrick Bertrand and B. Bouckaert and I. Demedts and P. Demuynck and E. Frans and E. Marchand and {on behalf of the Belgian Pulmonary Function Study Investigators}",
    year = "2015",
    month = "7",
    day = "22",
    doi = "10.1186/s12931-015-0252-0",
    language = "English",
    volume = "16",
    journal = "Respiratory Research",
    issn = "1465-9921",
    publisher = "BioMed Central",
    number = "1",

    }

    Topalovic, M, Derom, E, Osadnik, CR, Troosters, T, Decramer, M, Janssens, W, Vanherreweghe, R, Deman, R, Deryke, S, Ghesyens, B, Haerens, M, Maddens, S, Bultynck, W, Temmerman, W, Van Zandweghe, L, De Pauw, R, Depuydt, C, Haenebalcke, C, Ringoet, V, Van Renterghem, D, Carlier, A, Colle, D, De Cock, C, Lamont, J, Brancaleone, P, Vander Stappen, M, Peché, R, Pierard, A, Quarré, P, Van Meerhaeghe, A, Cataldo, D, Corhay, JL, Duysinx, B, Heinen, V, Naldi, M, Nguyen, D, Renaud, L, Cotils, M, Duchatelet, P, Gocmen, A, Lenclud, C, Lebrun, P, Noel, J, Frémault, A, Bertrand, P, Bouckaert, B, Demedts, I, Demuynck, P, Frans, E, Marchand, E & on behalf of the Belgian Pulmonary Function Study Investigators 2015, 'Airways resistance and specific conductance for the diagnosis of obstructive airways diseases' Respiratory Research, VOL. 16, Numéro 1, 88. DOI: 10.1186/s12931-015-0252-0

    Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. / Topalovic, Marko; Derom, Eric; Osadnik, Christian R.; Troosters, Thierry; Decramer, Marc; Janssens, Wim; Vanherreweghe, R.; Deman, R.; Deryke, S.; Ghesyens, B.; Haerens, M.; Maddens, S.; Bultynck, W.; Temmerman, W.; Van Zandweghe, L.; De Pauw, R.; Depuydt, C.; Haenebalcke, C.; Ringoet, V.; Van Renterghem, D.; Carlier, An; Colle, D.; De Cock, C.; Lamont, J.; Brancaleone, P.; Vander Stappen, M.; Peché, R.; Pierard, Annick; Quarré, P.; Van Meerhaeghe, Alain; Cataldo, Didier; Corhay, J. L.; Duysinx, B.; Heinen, V.; Naldi, M.; Nguyen, D.; Renaud, L.; Cotils, M.; Duchatelet, P.; Gocmen, A.; Lenclud, C.; Lebrun, Philippe; Noel, J.; Frémault, A.; Bertrand, Patrick; Bouckaert, B.; Demedts, I.; Demuynck, P.; Frans, E.; Marchand, E.; on behalf of the Belgian Pulmonary Function Study Investigators.

    Dans: Respiratory Research, Vol 16, Numéro 1, 88, 22.07.2015.

    Résultats de recherche: Contribution à un journal/une revueArticle

    TY - JOUR

    T1 - Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

    AU - Topalovic,Marko

    AU - Derom,Eric

    AU - Osadnik,Christian R.

    AU - Troosters,Thierry

    AU - Decramer,Marc

    AU - Janssens,Wim

    AU - Vanherreweghe,R.

    AU - Deman,R.

    AU - Deryke,S.

    AU - Ghesyens,B.

    AU - Haerens,M.

    AU - Maddens,S.

    AU - Bultynck,W.

    AU - Temmerman,W.

    AU - Van Zandweghe,L.

    AU - De Pauw,R.

    AU - Depuydt,C.

    AU - Haenebalcke,C.

    AU - Ringoet,V.

    AU - Van Renterghem,D.

    AU - Carlier,An

    AU - Colle,D.

    AU - De Cock,C.

    AU - Lamont,J.

    AU - Brancaleone,P.

    AU - Vander Stappen,M.

    AU - Peché,R.

    AU - Pierard,Annick

    AU - Quarré,P.

    AU - Van Meerhaeghe,Alain

    AU - Cataldo,Didier

    AU - Corhay,J. L.

    AU - Duysinx,B.

    AU - Heinen,V.

    AU - Naldi,M.

    AU - Nguyen,D.

    AU - Renaud,L.

    AU - Cotils,M.

    AU - Duchatelet,P.

    AU - Gocmen,A.

    AU - Lenclud,C.

    AU - Lebrun,Philippe

    AU - Noel,J.

    AU - Frémault,A.

    AU - Bertrand,Patrick

    AU - Bouckaert,B.

    AU - Demedts,I.

    AU - Demuynck,P.

    AU - Frans,E.

    AU - Marchand,E.

    AU - on behalf of the Belgian Pulmonary Function Study Investigators

    PY - 2015/7/22

    Y1 - 2015/7/22

    N2 - Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

    AB - Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

    KW - Airway resistance

    KW - Asthma

    KW - Body-plethysmography

    KW - Chronic obstructive pulmonary disease

    KW - Pulmonary function tests

    UR - http://www.scopus.com/inward/record.url?scp=84937250253&partnerID=8YFLogxK

    U2 - 10.1186/s12931-015-0252-0

    DO - 10.1186/s12931-015-0252-0

    M3 - Article

    VL - 16

    JO - Respiratory Research

    T2 - Respiratory Research

    JF - Respiratory Research

    SN - 1465-9921

    IS - 1

    M1 - 88

    ER -

    Topalovic M, Derom E, Osadnik CR, Troosters T, Decramer M, Janssens W et al. Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. Respiratory Research. 2015 juil. 22;16(1). 88. Disponible �, DOI: 10.1186/s12931-015-0252-0