Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

Marko Topalovic, Eric Derom, Christian R. Osadnik, Thierry Troosters, Marc Decramer, Wim Janssens, R. Vanherreweghe, R. Deman, S. Deryke, B. Ghesyens, M. Haerens, S. Maddens, W. Bultynck, W. Temmerman, L. Van Zandweghe, R. De Pauw, C. Depuydt, C. Haenebalcke, V. Ringoet, D. Van Renterghem & 31 others An Carlier, D. Colle, C. De Cock, J. Lamont, P. Brancaleone, M. Vander Stappen, R. Peché, Annick Pierard, P. Quarré, Alain Van Meerhaeghe, Didier Cataldo, J. L. Corhay, B. Duysinx, V. Heinen, M. Naldi, D. Nguyen, L. Renaud, M. Cotils, P. Duchatelet, A. Gocmen, C. Lenclud, Philippe Lebrun, J. Noel, A. Frémault, Patrick Bertrand, B. Bouckaert, I. Demedts, P. Demuynck, E. Frans, E. Marchand, on behalf of the Belgian Pulmonary Function Study Investigators

Research output: Contribution to journalArticle

Abstract

Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

LanguageEnglish
Article number88
JournalRespiratory Research
Volume16
Issue number1
DOIs
StatePublished - 22 Jul 2015
Externally publishedYes

Fingerprint

Airway Resistance
Asthma
Chronic Obstructive Pulmonary Disease
Belgium
Respiratory Function Tests
Airway Obstruction
Routine Diagnostic Tests
Lung Diseases
Healthy Volunteers
Physicians
Lung
Population

Keywords

  • Airway resistance
  • Asthma
  • Body-plethysmography
  • Chronic obstructive pulmonary disease
  • Pulmonary function tests

Cite this

Topalovic, M., Derom, E., Osadnik, C. R., Troosters, T., Decramer, M., Janssens, W., ... on behalf of the Belgian Pulmonary Function Study Investigators (2015). Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. Respiratory Research, 16(1), [88]. DOI: 10.1186/s12931-015-0252-0
Topalovic, Marko ; Derom, Eric ; Osadnik, Christian R. ; Troosters, Thierry ; Decramer, Marc ; Janssens, Wim ; Vanherreweghe, R. ; Deman, R. ; Deryke, S. ; Ghesyens, B. ; Haerens, M. ; Maddens, S. ; Bultynck, W. ; Temmerman, W. ; Van Zandweghe, L. ; De Pauw, R. ; Depuydt, C. ; Haenebalcke, C. ; Ringoet, V. ; Van Renterghem, D. ; Carlier, An ; Colle, D. ; De Cock, C. ; Lamont, J. ; Brancaleone, P. ; Vander Stappen, M. ; Peché, R. ; Pierard, Annick ; Quarré, P. ; Van Meerhaeghe, Alain ; Cataldo, Didier ; Corhay, J. L. ; Duysinx, B. ; Heinen, V. ; Naldi, M. ; Nguyen, D. ; Renaud, L. ; Cotils, M. ; Duchatelet, P. ; Gocmen, A. ; Lenclud, C. ; Lebrun, Philippe ; Noel, J. ; Frémault, A. ; Bertrand, Patrick ; Bouckaert, B. ; Demedts, I. ; Demuynck, P. ; Frans, E. ; Marchand, E. ; on behalf of the Belgian Pulmonary Function Study Investigators. / Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. In: Respiratory Research. 2015 ; Vol. 16, No. 1.
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abstract = "Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 {\%} and 18 {\%} of the population, respectively, in which 81 {\%} and 90 {\%} had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.",
keywords = "Airway resistance, Asthma, Body-plethysmography, Chronic obstructive pulmonary disease, Pulmonary function tests",
author = "Marko Topalovic and Eric Derom and Osadnik, {Christian R.} and Thierry Troosters and Marc Decramer and Wim Janssens and R. Vanherreweghe and R. Deman and S. Deryke and B. Ghesyens and M. Haerens and S. Maddens and W. Bultynck and W. Temmerman and {Van Zandweghe}, L. and {De Pauw}, R. and C. Depuydt and C. Haenebalcke and V. Ringoet and {Van Renterghem}, D. and An Carlier and D. Colle and {De Cock}, C. and J. Lamont and P. Brancaleone and {Vander Stappen}, M. and R. Pech{\'e} and Annick Pierard and P. Quarr{\'e} and {Van Meerhaeghe}, Alain and Didier Cataldo and Corhay, {J. L.} and B. Duysinx and V. Heinen and M. Naldi and D. Nguyen and L. Renaud and M. Cotils and P. Duchatelet and A. Gocmen and C. Lenclud and Philippe Lebrun and J. Noel and A. Fr{\'e}mault and Patrick Bertrand and B. Bouckaert and I. Demedts and P. Demuynck and E. Frans and E. Marchand and {on behalf of the Belgian Pulmonary Function Study Investigators}",
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Topalovic, M, Derom, E, Osadnik, CR, Troosters, T, Decramer, M, Janssens, W, Vanherreweghe, R, Deman, R, Deryke, S, Ghesyens, B, Haerens, M, Maddens, S, Bultynck, W, Temmerman, W, Van Zandweghe, L, De Pauw, R, Depuydt, C, Haenebalcke, C, Ringoet, V, Van Renterghem, D, Carlier, A, Colle, D, De Cock, C, Lamont, J, Brancaleone, P, Vander Stappen, M, Peché, R, Pierard, A, Quarré, P, Van Meerhaeghe, A, Cataldo, D, Corhay, JL, Duysinx, B, Heinen, V, Naldi, M, Nguyen, D, Renaud, L, Cotils, M, Duchatelet, P, Gocmen, A, Lenclud, C, Lebrun, P, Noel, J, Frémault, A, Bertrand, P, Bouckaert, B, Demedts, I, Demuynck, P, Frans, E, Marchand, E & on behalf of the Belgian Pulmonary Function Study Investigators 2015, 'Airways resistance and specific conductance for the diagnosis of obstructive airways diseases' Respiratory Research, vol. 16, no. 1, 88. DOI: 10.1186/s12931-015-0252-0

Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. / Topalovic, Marko; Derom, Eric; Osadnik, Christian R.; Troosters, Thierry; Decramer, Marc; Janssens, Wim; Vanherreweghe, R.; Deman, R.; Deryke, S.; Ghesyens, B.; Haerens, M.; Maddens, S.; Bultynck, W.; Temmerman, W.; Van Zandweghe, L.; De Pauw, R.; Depuydt, C.; Haenebalcke, C.; Ringoet, V.; Van Renterghem, D.; Carlier, An; Colle, D.; De Cock, C.; Lamont, J.; Brancaleone, P.; Vander Stappen, M.; Peché, R.; Pierard, Annick; Quarré, P.; Van Meerhaeghe, Alain; Cataldo, Didier; Corhay, J. L.; Duysinx, B.; Heinen, V.; Naldi, M.; Nguyen, D.; Renaud, L.; Cotils, M.; Duchatelet, P.; Gocmen, A.; Lenclud, C.; Lebrun, Philippe; Noel, J.; Frémault, A.; Bertrand, Patrick; Bouckaert, B.; Demedts, I.; Demuynck, P.; Frans, E.; Marchand, E.; on behalf of the Belgian Pulmonary Function Study Investigators.

In: Respiratory Research, Vol. 16, No. 1, 88, 22.07.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

AU - Topalovic,Marko

AU - Derom,Eric

AU - Osadnik,Christian R.

AU - Troosters,Thierry

AU - Decramer,Marc

AU - Janssens,Wim

AU - Vanherreweghe,R.

AU - Deman,R.

AU - Deryke,S.

AU - Ghesyens,B.

AU - Haerens,M.

AU - Maddens,S.

AU - Bultynck,W.

AU - Temmerman,W.

AU - Van Zandweghe,L.

AU - De Pauw,R.

AU - Depuydt,C.

AU - Haenebalcke,C.

AU - Ringoet,V.

AU - Van Renterghem,D.

AU - Carlier,An

AU - Colle,D.

AU - De Cock,C.

AU - Lamont,J.

AU - Brancaleone,P.

AU - Vander Stappen,M.

AU - Peché,R.

AU - Pierard,Annick

AU - Quarré,P.

AU - Van Meerhaeghe,Alain

AU - Cataldo,Didier

AU - Corhay,J. L.

AU - Duysinx,B.

AU - Heinen,V.

AU - Naldi,M.

AU - Nguyen,D.

AU - Renaud,L.

AU - Cotils,M.

AU - Duchatelet,P.

AU - Gocmen,A.

AU - Lenclud,C.

AU - Lebrun,Philippe

AU - Noel,J.

AU - Frémault,A.

AU - Bertrand,Patrick

AU - Bouckaert,B.

AU - Demedts,I.

AU - Demuynck,P.

AU - Frans,E.

AU - Marchand,E.

AU - on behalf of the Belgian Pulmonary Function Study Investigators

PY - 2015/7/22

Y1 - 2015/7/22

N2 - Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

AB - Background: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

KW - Airway resistance

KW - Asthma

KW - Body-plethysmography

KW - Chronic obstructive pulmonary disease

KW - Pulmonary function tests

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U2 - 10.1186/s12931-015-0252-0

DO - 10.1186/s12931-015-0252-0

M3 - Article

VL - 16

JO - Respiratory Research

T2 - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 1

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Topalovic M, Derom E, Osadnik CR, Troosters T, Decramer M, Janssens W et al. Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. Respiratory Research. 2015 Jul 22;16(1). 88. Available from, DOI: 10.1186/s12931-015-0252-0