Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Catherine Michaux; Bernadette Norberg; Jean-Michel Dogne; François Durant; Bernard Masereel; Jacques Delarge; Johan Wouters

doi:10.1107/S0108270100009872

Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Catherine Michaux, Bernadette Norberg, Jean-Michel Dogne, François Durant, Bernard Masereel, Jacques Delarge, Johan Wouters

Unit of theoretical and structural physico-chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Terbogrel, a mixed thromboxane A₂ receptor antagonist and thromboxane A₂ synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A₂ synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.

Original language	English
Pages (from-to)	1265-1266
Number of pages	2
Journal	Acta crystallographica. Section C: Crystal structure communications
Volume	56
Issue number	10
DOIs	https://doi.org/10.1107/S0108270100009872
Publication status	Published - 1 Oct 2000

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abstract = "Terbogrel, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.",

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AU - Michaux, Catherine

AU - Norberg, Bernadette

AU - Dogne, Jean-Michel

AU - Durant, François

AU - Masereel, Bernard

AU - Delarge, Jacques

AU - Wouters, Johan

PY - 2000/10/1

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AB - Terbogrel, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.

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M3 - Article

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Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

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