Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Research output: Contribution to journalArticlepeer-review

Abstract

Terbogrel, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.

Original languageEnglish
Pages (from-to)1265-1266
Number of pages2
JournalActa crystallographica Section C: Crystal Structure communications
Volume56
Issue number10
DOIs
Publication statusPublished - 1 Oct 2000

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