Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Catherine Michaux; Bernadette Norberg; Jean-Michel Dogne; François Durant; Bernard Masereel; Jacques Delarge; Johan Wouters

doi:10.1107/S0108270100009872

Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Catherine Michaux, Bernadette Norberg, Jean-Michel Dogne, François Durant, Bernard Masereel, Jacques Delarge, Johan Wouters

Unite de recherche en chimie physique, theorique et structurale

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Terbogrel, a mixed thromboxane A₂ receptor antagonist and thromboxane A₂ synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A₂ synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.

langue originale	Anglais
Pages (de - à)	1265-1266
Nombre de pages	2
journal	Acta crystallographica. Section C: Crystal structure communications
Volume	56
Numéro de publication	10
Les DOIs	https://doi.org/10.1107/S0108270100009872
Etat de la publication	Publié - 1 oct. 2000

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10.1107/S0108270100009872

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title = "Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition",

abstract = "Terbogrel, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.",

author = "Catherine Michaux and Bernadette Norberg and Jean-Michel Dogne and Fran{\c c}ois Durant and Bernard Masereel and Jacques Delarge and Johan Wouters",

year = "2000",

month = oct,

day = "1",

doi = "10.1107/S0108270100009872",

language = "English",

volume = "56",

pages = "1265--1266",

journal = "Acta crystallographica. Section C: Crystal structure communications",

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Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition. / Michaux, Catherine ; Norberg, Bernadette ; Dogne, Jean-Michel et al.
Dans: Acta crystallographica. Section C: Crystal structure communications, Vol 56, Numéro 10, 01.10.2000, p. 1265-1266.

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

TY - JOUR

T1 - Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

AU - Michaux, Catherine

AU - Norberg, Bernadette

AU - Dogne, Jean-Michel

AU - Durant, François

AU - Masereel, Bernard

AU - Delarge, Jacques

AU - Wouters, Johan

PY - 2000/10/1

Y1 - 2000/10/1

N2 - Terbogrel, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.

AB - Terbogrel, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed. The structural properties of the compound are studied to understand the dual mode of action. H atoms were located in difference Fourier maps and then refined.

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U2 - 10.1107/S0108270100009872

DO - 10.1107/S0108270100009872

M3 - Article

AN - SCOPUS:0034294087

SN - 0108-2701

VL - 56

SP - 1265

EP - 1266

JO - Acta crystallographica. Section C: Crystal structure communications

JF - Acta crystallographica. Section C: Crystal structure communications

IS - 10

ER -

Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

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