Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

Shouxia Wang, Zhiyi Hu, Jie Hu, Zhiming Qiu, Junli Li, Wei Geng, Baolian Su, Xiaoyu Yang

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy (1H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.

Original languageEnglish
Pages (from-to)658-664
Number of pages7
JournalJournal Wuhan University of Technology, Materials Science Edition
Volume35
Issue number3
DOIs
Publication statusPublished - 1 Jun 2020

Keywords

  • controlled drug release
  • core-shell structure
  • mesoporous silica materials

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