Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

Shouxia Wang; Zhiyi Hu; Jie Hu; Zhiming Qiu; Junli Li; Wei Geng; Baolian Su; Xiaoyu Yang

doi:10.1007/s11595-020-2303-8

Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

Shouxia Wang, Zhiyi Hu, Jie Hu, Zhiming Qiu, Junli Li, Wei Geng, Baolian Su, Xiaoyu Yang

University of Namur

Research output: Contribution to journal › Article › peer-review

Abstract

We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy (¹H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.

Original language	English
Pages (from-to)	658-664
Number of pages	7
Journal	Journal Wuhan University of Technology, Materials Science Edition
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s11595-020-2303-8
Publication status	Published - 1 Jun 2020

Keywords

controlled drug release
core-shell structure
mesoporous silica materials

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10.1007/s11595-020-2303-8

Cite this

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title = "Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier",

abstract = "We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy (1H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.",

keywords = "controlled drug release, core-shell structure, mesoporous silica materials",

author = "Shouxia Wang and Zhiyi Hu and Jie Hu and Zhiming Qiu and Junli Li and Wei Geng and Baolian Su and Xiaoyu Yang",

year = "2020",

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doi = "10.1007/s11595-020-2303-8",

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TY - JOUR

T1 - Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

AU - Wang, Shouxia

AU - Hu, Zhiyi

AU - Hu, Jie

AU - Qiu, Zhiming

AU - Li, Junli

AU - Geng, Wei

AU - Su, Baolian

AU - Yang, Xiaoyu

PY - 2020/6/1

Y1 - 2020/6/1

N2 - We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy (1H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.

AB - We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy (1H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.

KW - controlled drug release

KW - core-shell structure

KW - mesoporous silica materials

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M3 - Article

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JO - Journal Wuhan University of Technology, Materials Science Edition

JF - Journal Wuhan University of Technology, Materials Science Edition

IS - 3

ER -

Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

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Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

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