Synthesis of D-glycero-D-manno-heptose 1,7-bisphosphate (HBP) featuring a β-stereoselective bis-phosphorylation

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Abstract

D-glycero-D-manno-Heptose 1,7-bisphosphate (HBP) plays a unique role in bacteriology. We describe in this study a very efficient synthesis of HBP, featuring a highly 6-D-selective construction of the heptose scaffold as well as a double phosphorylation step installing, in a single operation and in a β-stereoselective manner, the 1- and the 7-phosphates.

Original languageEnglish
Pages (from-to)3631-3633
Number of pages3
JournalTetrahedron Letters
Volume58
Issue number37
DOIs
Publication statusPublished - 13 Sep 2017

Keywords

  • Bacterial saccharides
  • Carbohydrates
  • Glycosidation
  • Phosphorylation

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