Recent advances in BLV research

P.-Y. Barez, Alix de Brogniez, A. Carpentier, H. Gazon, N. Gillet, A. Gutiérrez-Moraga, M. Hamaïdia, J.-R. Jacques, S. Perike, S. Neelature Sriramareddy, N. Renotte, B. Staumont, M. Reichert, K. Trono, L. Willems

Research output: Contribution to journalArticlepeer-review

Abstract

[en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.
Original languageEnglish
Pages (from-to)6080-6088
Number of pages9
JournalViruses
Volume7
Issue number11
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Sciences de la santé humaine => Oncologie
  • BLV
  • HTLV-1
  • Tax
  • microRNA
  • vaccine
  • HDAC

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