Recent advances in BLV research

P.-Y. Barez; Alix de Brogniez; A. Carpentier; H. Gazon; N. Gillet; A. Gutiérrez-Moraga; M. Hamaïdia; J.-R. Jacques; S. Perike; S. Neelature Sriramareddy; N. Renotte; B. Staumont; M. Reichert; K. Trono; L. Willems

doi:10.3390/v7112929

Recent advances in BLV research

P.-Y. Barez, Alix de Brogniez, A. Carpentier, H. Gazon, N. Gillet, A. Gutiérrez-Moraga, M. Hamaïdia, J.-R. Jacques, S. Perike, S. Neelature Sriramareddy, N. Renotte, B. Staumont, M. Reichert, K. Trono, L. Willems

Research output: Contribution to journal › Article › peer-review

Abstract

[en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

Original language	English
Pages (from-to)	6080-6088
Number of pages	9
Journal	Viruses
Volume	7
Issue number	11
DOIs	https://doi.org/10.3390/v7112929
Publication status	Published - 2015
Externally published	Yes

Keywords

Sciences de la santé humaine => Oncologie
BLV
HTLV-1
Tax
microRNA
vaccine
HDAC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v7112929

http://hdl.handle.net/2268/188454; http://www.mdpi.com/1999-4915/7/11/2929

Cite this

@article{55df6e51443244fe938b27749bb90cf7,

title = "Recent advances in BLV research",

abstract = "[en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.",

keywords = "Sciences de la sant{\'e} humaine => Oncologie, BLV, HTLV-1, Tax, microRNA, vaccine, HDAC",

author = "P.-Y. Barez and Brogniez, {Alix de} and A. Carpentier and H. Gazon and N. Gillet and A. Guti{\'e}rrez-Moraga and M. Hama{\"i}dia and J.-R. Jacques and S. Perike and {Neelature Sriramareddy}, S. and N. Renotte and B. Staumont and M. Reichert and K. Trono and L. Willems",

year = "2015",

doi = "10.3390/v7112929",

language = "English",

volume = "7",

pages = "6080--6088",

journal = "Viruses",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Recent advances in BLV research

AU - Barez, P.-Y.

AU - Brogniez, Alix de

AU - Carpentier, A.

AU - Gazon, H.

AU - Gillet, N.

AU - Gutiérrez-Moraga, A.

AU - Hamaïdia, M.

AU - Jacques, J.-R.

AU - Perike, S.

AU - Neelature Sriramareddy, S.

AU - Renotte, N.

AU - Staumont, B.

AU - Reichert, M.

AU - Trono, K.

AU - Willems, L.

PY - 2015

Y1 - 2015

N2 - [en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

AB - [en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

KW - Sciences de la santé humaine => Oncologie

KW - BLV

KW - HTLV-1

KW - Tax

KW - microRNA

KW - vaccine

KW - HDAC

U2 - 10.3390/v7112929

DO - 10.3390/v7112929

M3 - Article

VL - 7

SP - 6080

EP - 6088

JO - Viruses

JF - Viruses

IS - 11

ER -

Recent advances in BLV research

Abstract

Keywords

UN SDGs

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