Recent advances in BLV research

P.-Y. Barez, Alix de Brogniez, A. Carpentier, H. Gazon, N. Gillet, A. Gutiérrez-Moraga, M. Hamaïdia, J.-R. Jacques, S. Perike, S. Neelature Sriramareddy, N. Renotte, B. Staumont, M. Reichert, K. Trono, L. Willems

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

[en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.
langue originaleAnglais
Pages (de - à)6080-6088
Nombre de pages9
journalViruses
Volume7
Numéro de publication11
Les DOIs
étatPublié - 2015
Modification externeOui

Empreinte digitale

Bovine Leukemia Virus
Transgenic Rats
Deltaretrovirus
Species Specificity
Saimiri
Virology
Human T-lymphotropic virus 1
Lymphoproliferative Disorders
Papio
Ruminants
Macaca
Research
Animal Models
Rabbits
Therapeutics

Citer ceci

Barez, P-Y., Brogniez, A. D., Carpentier, A., Gazon, H., Gillet, N., Gutiérrez-Moraga, A., ... Willems, L. (2015). Recent advances in BLV research. Viruses, 7(11), 6080-6088. https://doi.org/10.3390/v7112929
Barez, P.-Y. ; Brogniez, Alix de ; Carpentier, A. ; Gazon, H. ; Gillet, N. ; Gutiérrez-Moraga, A. ; Hamaïdia, M. ; Jacques, J.-R. ; Perike, S. ; Neelature Sriramareddy, S. ; Renotte, N. ; Staumont, B. ; Reichert, M. ; Trono, K. ; Willems, L. / Recent advances in BLV research. Dans: Viruses. 2015 ; Vol 7, Numéro 11. p. 6080-6088.
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title = "Recent advances in BLV research",
abstract = "[en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.",
keywords = "Sciences de la sant{\'e} humaine => Oncologie, BLV, HTLV-1, Tax, microRNA, vaccine, HDAC",
author = "P.-Y. Barez and Brogniez, {Alix de} and A. Carpentier and H. Gazon and N. Gillet and A. Guti{\'e}rrez-Moraga and M. Hama{\"i}dia and J.-R. Jacques and S. Perike and {Neelature Sriramareddy}, S. and N. Renotte and B. Staumont and M. Reichert and K. Trono and L. Willems",
year = "2015",
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language = "English",
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Barez, P-Y, Brogniez, AD, Carpentier, A, Gazon, H, Gillet, N, Gutiérrez-Moraga, A, Hamaïdia, M, Jacques, J-R, Perike, S, Neelature Sriramareddy, S, Renotte, N, Staumont, B, Reichert, M, Trono, K & Willems, L 2015, 'Recent advances in BLV research', Viruses, VOL. 7, Numéro 11, p. 6080-6088. https://doi.org/10.3390/v7112929

Recent advances in BLV research. / Barez, P.-Y.; Brogniez, Alix de; Carpentier, A.; Gazon, H.; Gillet, N.; Gutiérrez-Moraga, A.; Hamaïdia, M.; Jacques, J.-R.; Perike, S.; Neelature Sriramareddy, S.; Renotte, N.; Staumont, B.; Reichert, M.; Trono, K.; Willems, L.

Dans: Viruses, Vol 7, Numéro 11, 2015, p. 6080-6088.

Résultats de recherche: Contribution à un journal/une revueArticle

TY - JOUR

T1 - Recent advances in BLV research

AU - Barez, P.-Y.

AU - Brogniez, Alix de

AU - Carpentier, A.

AU - Gazon, H.

AU - Gillet, N.

AU - Gutiérrez-Moraga, A.

AU - Hamaïdia, M.

AU - Jacques, J.-R.

AU - Perike, S.

AU - Neelature Sriramareddy, S.

AU - Renotte, N.

AU - Staumont, B.

AU - Reichert, M.

AU - Trono, K.

AU - Willems, L.

PY - 2015

Y1 - 2015

N2 - [en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

AB - [en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/gamma cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

KW - Sciences de la santé humaine => Oncologie

KW - BLV

KW - HTLV-1

KW - Tax

KW - microRNA

KW - vaccine

KW - HDAC

U2 - 10.3390/v7112929

DO - 10.3390/v7112929

M3 - Article

VL - 7

SP - 6080

EP - 6088

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 11

ER -

Barez P-Y, Brogniez AD, Carpentier A, Gazon H, Gillet N, Gutiérrez-Moraga A et al. Recent advances in BLV research. Viruses. 2015;7(11):6080-6088. https://doi.org/10.3390/v7112929