In vitro irradiation station for broad beam radiobiological experiments

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Abstract

The study of the interaction of charged particles with living matter is of prime importance to the fields of radiotherapy, radioprotection and space radiobiology. Particle accelerators and their associated equipment are proven to be helpful tools in performing basic science in all these fields. Indeed, they can accelerate virtually any ions to a given energy and flux and let them interact with living matter either in vivo or in vitro. In this context, the University of Namur has developed a broad beam in vitro irradiation station for use in radiobiological experiments. Cells are handled in GLP conditions and can be irradiated at various fluxes with ions ranging from hydrogen to carbon. The station is mounted on a 2 MV tandem accelerator, and the energy range can be set up in the linear energy transfer (LET) ranges that are useful for radiobiological experiments. This paper describes the current status of the hardware that has been developed, and presents results related to its performance in term of dose-rate, energy range and beam uniformity for protons, alpha particles and carbon ions. The results of clonogenic assays of A549 lung adenocarcinoma cells irradiated with protons and alpha particles are also presented and compared with literature.
Original languageEnglish
Pages (from-to)3120-3124
Number of pages5
JournalNuclear instruments and methods in physics research B
Volume269
Issue number24
DOIs
Publication statusPublished - 2011

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    • 2 Participation in conference
    • 1 Participation in workshop, seminar, course

    Workshop on Translational Research in Ion Beam Cancer Therapy (TRIBCT)

    Stéphane Lucas (Speaker)

    30 Sep 20142 Oct 2014

    Activity: Participating in or organising an event typesParticipation in conference

    11th International Topical Meeting on Nuclera Applications of Accelerators (AccApp2013)

    Stéphane Lucas (Member of Organizing Committee)

    5 Aug 20138 Aug 2013

    Activity: Participating in or organising an event typesParticipation in conference

    Belgian Hadron-Therapy (SCK-CEN / UZ Gent)

    Stéphane Lucas (Participant)

    20 Apr 2012

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

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