Endosomes, lysosomes: Their implication in gene transfer

Research output: Contribution to journalArticlepeer-review


Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it has to travel through the intracellular endocytic pathway involving endosomes and lysosomes. However, some DNA molecules must escape these organelles to reach the nucleus where transcription takes place. In this paper, we consider different factors that could affect the trafficking of plasmid DNA and influence transfection efficiency.
Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalAdvanced Drug Delivery Reviews
Issue number2
Publication statusPublished - 30 Mar 2000


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