Endosomes, lysosomes: Their implication in gene transfer

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it has to travel through the intracellular endocytic pathway involving endosomes and lysosomes. However, some DNA molecules must escape these organelles to reach the nucleus where transcription takes place. In this paper, we consider different factors that could affect the trafficking of plasmid DNA and influence transfection efficiency.
langue originaleAnglais
Pages (de - à)201-208
Nombre de pages8
journalAdvanced Drug Delivery Reviews
Volume41
Numéro de publication2
Les DOIs
Etat de la publicationPublié - 30 mars 2000

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