Chemotherapy-induced resistance by ATP-binding cassette transporter genes

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A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

Original languageEnglish
Pages (from-to)237-62
Number of pages26
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Issue number2
Publication statusPublished - 2007


  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • Crystallography, X-Ray
  • Drug Resistance
  • Genetic Therapy
  • Humans
  • Neoplasms
  • Protein Conformation
  • Stem Cells


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