Chemotherapy-induced resistance by ATP-binding cassette transporter genes

Research output: Contribution to journalLiterature review

Abstract

A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

Original languageEnglish
Pages (from-to)237-62
Number of pages26
JournalBiochimica Biophysica Acta.
Volume1775
Issue number2
DOIs
Publication statusPublished - 2007

Keywords

  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • Crystallography, X-Ray
  • Drug Resistance
  • Genetic Therapy
  • Humans
  • Neoplasms
  • Protein Conformation
  • Stem Cells

Fingerprint Dive into the research topics of 'Chemotherapy-induced resistance by ATP-binding cassette transporter genes'. Together they form a unique fingerprint.

  • Cite this