Chemotherapy-induced resistance by ATP-binding cassette transporter genes

Research output: Contribution to journalLiterature review

Abstract

A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

Original languageEnglish
Pages (from-to)237-62
Number of pages26
JournalBiochimica Biophysica Acta.
Volume1775
Issue number2
DOIs
Publication statusPublished - 2007

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ATP-Binding Cassette Transporters
Drug Therapy
Genes
Multiple Drug Resistance
Pharmaceutical Preparations
Neoplasms
Growth
Therapeutics

Keywords

  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • Crystallography, X-Ray
  • Drug Resistance
  • Genetic Therapy
  • Humans
  • Neoplasms
  • Protein Conformation
  • Stem Cells

Cite this

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title = "Chemotherapy-induced resistance by ATP-binding cassette transporter genes",
abstract = "A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.",
keywords = "ATP-Binding Cassette Transporters, Antineoplastic Agents, Crystallography, X-Ray, Drug Resistance, Genetic Therapy, Humans, Neoplasms, Protein Conformation, Stem Cells",
author = "Jean-Pierre Gillet and Thomas Efferth and Jos{\'e} Remacle",
year = "2007",
doi = "10.1016/j.bbcan.2007.05.002",
language = "English",
volume = "1775",
pages = "237--62",
journal = "Biochimica Biophysica Acta.",
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Chemotherapy-induced resistance by ATP-binding cassette transporter genes. / Gillet, Jean-Pierre; Efferth, Thomas; Remacle, José.

In: Biochimica Biophysica Acta. , Vol. 1775, No. 2, 2007, p. 237-62.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Chemotherapy-induced resistance by ATP-binding cassette transporter genes

AU - Gillet, Jean-Pierre

AU - Efferth, Thomas

AU - Remacle, José

PY - 2007

Y1 - 2007

N2 - A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

AB - A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

KW - ATP-Binding Cassette Transporters

KW - Antineoplastic Agents

KW - Crystallography, X-Ray

KW - Drug Resistance

KW - Genetic Therapy

KW - Humans

KW - Neoplasms

KW - Protein Conformation

KW - Stem Cells

U2 - 10.1016/j.bbcan.2007.05.002

DO - 10.1016/j.bbcan.2007.05.002

M3 - Literature review

C2 - 17572300

VL - 1775

SP - 237

EP - 262

JO - Biochimica Biophysica Acta.

JF - Biochimica Biophysica Acta.

SN - 0006-3002

IS - 2

ER -