Chemotherapy-induced resistance by ATP-binding cassette transporter genes

Jean-Pierre Gillet; Thomas Efferth; José Remacle

doi:10.1016/j.bbcan.2007.05.002

Chemotherapy-induced resistance by ATP-binding cassette transporter genes

Jean-Pierre Gillet, Thomas Efferth, José Remacle

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Résumé

A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

langue originale	Anglais
Pages (de - à)	237-62
Nombre de pages	26
journal	Biochimica et Biophysica Acta - Reviews on Cancer
Volume	1775
Numéro de publication	2
Les DOIs	https://doi.org/10.1016/j.bbcan.2007.05.002
Etat de la publication	Publié - 2007

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10.1016/j.bbcan.2007.05.002

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@article{30e47afd806f416596a44b3b7b02ca81,

title = "Chemotherapy-induced resistance by ATP-binding cassette transporter genes",

abstract = "A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.",

keywords = "ATP-Binding Cassette Transporters, Antineoplastic Agents, Crystallography, X-Ray, Drug Resistance, Genetic Therapy, Humans, Neoplasms, Protein Conformation, Stem Cells",

author = "Jean-Pierre Gillet and Thomas Efferth and Jos{\'e} Remacle",

year = "2007",

doi = "10.1016/j.bbcan.2007.05.002",

language = "English",

volume = "1775",

pages = "237--62",

journal = "Biochimica et Biophysica Acta - Reviews on Cancer",

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TY - JOUR

T1 - Chemotherapy-induced resistance by ATP-binding cassette transporter genes

AU - Gillet, Jean-Pierre

AU - Efferth, Thomas

AU - Remacle, José

PY - 2007

Y1 - 2007

N2 - A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

AB - A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

KW - ATP-Binding Cassette Transporters

KW - Antineoplastic Agents

KW - Crystallography, X-Ray

KW - Drug Resistance

KW - Genetic Therapy

KW - Humans

KW - Neoplasms

KW - Protein Conformation

KW - Stem Cells

U2 - 10.1016/j.bbcan.2007.05.002

DO - 10.1016/j.bbcan.2007.05.002

M3 - Literature review

C2 - 17572300

SN - 0304-419X

VL - 1775

SP - 237

EP - 262

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

IS - 2

ER -

Chemotherapy-induced resistance by ATP-binding cassette transporter genes

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