C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Lucas Schoenauen; François-Xavier Stubbe; Dirk Van Gestel; Sébastien Penninckx; Anne-Catherine Heuskin

doi:10.1016/j.ctro.2023.100712

C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Lucas Schoenauen, François-Xavier Stubbe, Dirk Van Gestel, Sébastien Penninckx, Anne-Catherine Heuskin

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Abstract

This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C. elegans suitability as a screening model for studying the LET impact on the FLASH effect, reinforcing its potential in radiation research.

Original language	English
Article number	100712
Pages (from-to)	100712
Journal	Clinical and translational radiation oncology
Volume	45
DOIs	https://doi.org/10.1016/j.ctro.2023.100712
Publication status	Published - Mar 2024

Keywords

C. elegans embryo
Electron flash
Proton flash

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ctro.2023.100712

231218_ART_Schoenauen2023Final published version, 486 KBLicence: CC BY

Cite this

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title = "C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.",

abstract = "This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C. elegans suitability as a screening model for studying the LET impact on the FLASH effect, reinforcing its potential in radiation research. ",

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AU - Penninckx, Sébastien

AU - Heuskin, Anne-Catherine

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KW - C. elegans embryo

KW - Electron flash

KW - Proton flash

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C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Abstract

Keywords

UN SDGs

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EPT: Emerging Proton Therapies

Investigation of the beam parameters to trigger the FLASH effect with a proton beam.

Synthesis, Irradiation and Analysis of Materials (SIAM)

Transcriptional Control of a Developmental Transition in Caenorhabditis elegans

Cite this

C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect.

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

EPT: Emerging Proton Therapies

Investigation of the beam parameters to trigger the FLASH effect with a proton beam.

Equipment

Synthesis, Irradiation and Analysis of Materials (SIAM)

Student theses

Transcriptional Control of a Developmental Transition in Caenorhabditis elegans

Cite this