TY - JOUR
T1 - Brucella adaptation and survival at the crossroad of metabolism and virulence
AU - Barbier, T.
AU - Nicolas, C.
AU - Letesson, Jean-Jacques
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2011/10/3
Y1 - 2011/10/3
N2 - "In vivo" bacterial nutrition, i.e. the nature of the metabolic network and substrate(s) used by bacteria within their host, is a fundamental aspect of pathogenic or symbiotic lifestyles. A typical example are the Brucella spp., facultative intracellular pathogens responsible for chronic infections of animals and humans. Their virulence relies on their ability to modulate immune response and the physiology of host cells, but the fine-tuning of their metabolism in the host during infection appears increasingly crucial. Here we review new insights on the links between Brucella virulence and metabolism, pointing out the need to investigate both aspects to decipher Brucella infectious strategies.
AB - "In vivo" bacterial nutrition, i.e. the nature of the metabolic network and substrate(s) used by bacteria within their host, is a fundamental aspect of pathogenic or symbiotic lifestyles. A typical example are the Brucella spp., facultative intracellular pathogens responsible for chronic infections of animals and humans. Their virulence relies on their ability to modulate immune response and the physiology of host cells, but the fine-tuning of their metabolism in the host during infection appears increasingly crucial. Here we review new insights on the links between Brucella virulence and metabolism, pointing out the need to investigate both aspects to decipher Brucella infectious strategies.
UR - http://www.scopus.com/inward/record.url?scp=80053222651&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2011.08.011
DO - 10.1016/j.febslet.2011.08.011
M3 - Article
AN - SCOPUS:80053222651
SN - 0014-5793
VL - 585
SP - 2929
EP - 2934
JO - FEBS Letters
JF - FEBS Letters
IS - 19
ER -