Projects per year
Abstract
"In vivo" bacterial nutrition, i.e. the nature of the metabolic network and substrate(s) used by bacteria within their host, is a fundamental aspect of pathogenic or symbiotic lifestyles. A typical example are the Brucella spp., facultative intracellular pathogens responsible for chronic infections of animals and humans. Their virulence relies on their ability to modulate immune response and the physiology of host cells, but the fine-tuning of their metabolism in the host during infection appears increasingly crucial. Here we review new insights on the links between Brucella virulence and metabolism, pointing out the need to investigate both aspects to decipher Brucella infectious strategies.
Original language | English |
---|---|
Pages (from-to) | 2929-2934 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 585 |
Issue number | 19 |
DOIs | |
Publication status | Published - 3 Oct 2011 |
Fingerprint Dive into the research topics of 'Brucella adaptation and survival at the crossroad of metabolism and virulence'. Together they form a unique fingerprint.
Projects
- 2 Finished
-
Adaptation métabolique de Brucella en cours d'infection: Impact sur la virulence
1/10/10 → 30/09/14
Project: PHD
-
Equipment
-
Biological Security Laboratory Level 3 (BL3)
Xavier De Bolle (Manager)
Technological Platform: Biological Security Laboratory Level 3Facility/equipment: Technological Platform