Brucella adaptation and survival at the crossroad of metabolism and virulence

T. Barbier; C. Nicolas; Jean-Jacques Letesson

doi:10.1016/j.febslet.2011.08.011

Brucella adaptation and survival at the crossroad of metabolism and virulence

T. Barbier, C. Nicolas, Jean-Jacques Letesson

Research output: Contribution to journal › Article

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Abstract

"In vivo" bacterial nutrition, i.e. the nature of the metabolic network and substrate(s) used by bacteria within their host, is a fundamental aspect of pathogenic or symbiotic lifestyles. A typical example are the Brucella spp., facultative intracellular pathogens responsible for chronic infections of animals and humans. Their virulence relies on their ability to modulate immune response and the physiology of host cells, but the fine-tuning of their metabolism in the host during infection appears increasingly crucial. Here we review new insights on the links between Brucella virulence and metabolism, pointing out the need to investigate both aspects to decipher Brucella infectious strategies.

Original language	English
Pages (from-to)	2929-2934
Number of pages	6
Journal	FEBS Letters
Volume	585
Issue number	19
DOIs	https://doi.org/10.1016/j.febslet.2011.08.011
Publication status	Published - 3 Oct 2011

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Brucella

Metabolism

Virulence

Survival

Physiology

Pathogens

Nutrition

Cell Physiological Phenomena

Bacteria

Animals

Aptitude

Tuning

Metabolic Networks and Pathways

Infection

Life Style

Substrates

Cite this

Barbier, T., Nicolas, C., & Letesson, J-J. (2011). Brucella adaptation and survival at the crossroad of metabolism and virulence. FEBS Letters, 585(19), 2929-2934. https://doi.org/10.1016/j.febslet.2011.08.011

Barbier, T. ; Nicolas, C. ; Letesson, Jean-Jacques. / Brucella adaptation and survival at the crossroad of metabolism and virulence. In: FEBS Letters. 2011 ; Vol. 585, No. 19. pp. 2929-2934.

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Barbier, T , Nicolas, C & Letesson, J-J 2011, 'Brucella adaptation and survival at the crossroad of metabolism and virulence', FEBS Letters, vol. 585, no. 19, pp. 2929-2934. https://doi.org/10.1016/j.febslet.2011.08.011

Brucella adaptation and survival at the crossroad of metabolism and virulence. / Barbier, T.; Nicolas, C.; Letesson, Jean-Jacques.

In: FEBS Letters, Vol. 585, No. 19, 03.10.2011, p. 2929-2934.

Research output: Contribution to journal › Article

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