Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives

F. Pérez-Cruz, S. Serra, G. Delogu, M. Lapier, J.D. Maya, C. Olea-Azar, L. Santana, E. Uriarte

Research output: Contribution to journalArticlepeer-review


In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, and the antioxidant properties. We have used the 4-hydroxycoumarin moiety (compound 1) as the molecular template for the synthesis of compounds 2-7. These derivates have shown moderate trypanocidal activity. However they have been proved to be good antioxidants. In particular compound 7 is the most active antioxidant and it is, therefore, a potential candidate for a successful employment in conditions characterized by free radicals overproduction.
Original languageEnglish
Pages (from-to)5569-5573
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Issue number17
Publication statusPublished - 1 Sep 2012


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