TY - JOUR
T1 - Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives
AU - Pérez-Cruz, F.
AU - Serra, S.
AU - Delogu, G.
AU - Lapier, M.
AU - Maya, J.D.
AU - Olea-Azar, C.
AU - Santana, L.
AU - Uriarte, E.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, and the antioxidant properties. We have used the 4-hydroxycoumarin moiety (compound 1) as the molecular template for the synthesis of compounds 2-7. These derivates have shown moderate trypanocidal activity. However they have been proved to be good antioxidants. In particular compound 7 is the most active antioxidant and it is, therefore, a potential candidate for a successful employment in conditions characterized by free radicals overproduction.
AB - In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, and the antioxidant properties. We have used the 4-hydroxycoumarin moiety (compound 1) as the molecular template for the synthesis of compounds 2-7. These derivates have shown moderate trypanocidal activity. However they have been proved to be good antioxidants. In particular compound 7 is the most active antioxidant and it is, therefore, a potential candidate for a successful employment in conditions characterized by free radicals overproduction.
UR - http://www.scopus.com/inward/record.url?scp=84865145129&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2012.07.013
DO - 10.1016/j.bmcl.2012.07.013
M3 - Article
AN - SCOPUS:84865145129
SN - 0960-894X
VL - 22
SP - 5569
EP - 5573
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 17
ER -