Ageing of hamster embryo fibroblasts as the result of both differentiation and stochastic mechanisms

Research output: Contribution to journalArticle

Abstract

Fibroblasts from hamster embryos were serially cultivated in vitro and their evolution followed from a morphological, physiological and biochemical point of view. After an exponential growth for about 20 passages, cells entered the aging phase which ended up after 29-34 passages. From our observations, it seems that the arrest of growth results from two different phenomena: first, the typically fibroblastic cells may undergo a stochastic aging process; second, some of these cells evolve into a terminal differentiation process, characterized by a different non-fibroblastic phenotype.
Original languageEnglish
Pages (from-to)223-240
Number of pages18
JournalExperimental Gerontology
Volume18
Issue number3
DOIs
Publication statusPublished - 1 Jan 1983

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