TY - JOUR
T1 - Ageing of hamster embryo fibroblasts as the result of both differentiation and stochastic mechanisms
AU - Raes, Martine
AU - Remacle, J.
N1 - Medline is the source for the MeSH terms of this document.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Fibroblasts from hamster embryos were serially cultivated in vitro and their evolution followed from a morphological, physiological and biochemical point of view. After an exponential growth for about 20 passages, cells entered the aging phase which ended up after 29-34 passages. From our observations, it seems that the arrest of growth results from two different phenomena: first, the typically fibroblastic cells may undergo a stochastic aging process; second, some of these cells evolve into a terminal differentiation process, characterized by a different non-fibroblastic phenotype.
AB - Fibroblasts from hamster embryos were serially cultivated in vitro and their evolution followed from a morphological, physiological and biochemical point of view. After an exponential growth for about 20 passages, cells entered the aging phase which ended up after 29-34 passages. From our observations, it seems that the arrest of growth results from two different phenomena: first, the typically fibroblastic cells may undergo a stochastic aging process; second, some of these cells evolve into a terminal differentiation process, characterized by a different non-fibroblastic phenotype.
UR - http://www.scopus.com/inward/record.url?scp=0020546056&partnerID=8YFLogxK
U2 - 10.1016/0531-5565(83)90034-7
DO - 10.1016/0531-5565(83)90034-7
M3 - Article
AN - SCOPUS:0020546056
SN - 0531-5565
VL - 18
SP - 223
EP - 240
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 3
ER -