Projects per year
Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together,either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of L-Proline and MnCl 2. In that context,a new crystalline structure of a multicomponent molecular complex composed of L-Proline and MnCl2 is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally,our work provides structural basis for the role that L-Proline can play within multicomponent solid-state molecular complexes,in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest.
- Crystal structure
- Multicomponent molecularcomplex
Etude physico-chimique et structurale du polymorphisme cristallin d'anticancéreux potentiels : la cocristallisation comme solution au problème de solubilité.
TILBORG, A. & WOUTERS, J.
1/10/09 → 30/09/13