Advantages of cocrystallization in the field of solid-statepharmaceutical chemistry: L-Proline and MnCl2

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Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together,either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of L-Proline and MnCl 2. In that context,a new crystalline structure of a multicomponent molecular complex composed of L-Proline and MnCl2 is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally,our work provides structural basis for the role that L-Proline can play within multicomponent solid-state molecular complexes,in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest.

Original languageEnglish
Pages (from-to)3511-3517
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Issue number8
Publication statusPublished - 1 Aug 2010


  • Cocrystallization
  • Crystal structure
  • L-Proline
  • Multicomponent molecularcomplex

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    CCDC 757598: Experimental Crystal Structure Determination

    Michaux, C. (Contributor), NORBERG, B. (Contributor), Tilborg, A. (Contributor) & WOUTERS, J. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2012


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