Advantages of cocrystallization in the field of solid-statepharmaceutical chemistry: L-Proline and MnCl2

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together,either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of L-Proline and MnCl 2. In that context,a new crystalline structure of a multicomponent molecular complex composed of L-Proline and MnCl2 is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally,our work provides structural basis for the role that L-Proline can play within multicomponent solid-state molecular complexes,in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest.

langue originaleAnglais
Pages (de - à)3511-3517
Nombre de pages7
journalEuropean Journal of Medicinal Chemistry
Volume45
Numéro de publication8
Les DOIs
Etat de la publicationPublié - 1 août 2010

Empreinte digitale

Examiner les sujets de recherche de « Advantages of cocrystallization in the field of solid-statepharmaceutical chemistry: L-Proline and MnCl<sub>2</sub> ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation