Projets par an
Résumé
Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together,either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of L-Proline and MnCl 2. In that context,a new crystalline structure of a multicomponent molecular complex composed of L-Proline and MnCl2 is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally,our work provides structural basis for the role that L-Proline can play within multicomponent solid-state molecular complexes,in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest.
langue originale | Anglais |
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Pages (de - à) | 3511-3517 |
Nombre de pages | 7 |
journal | European Journal of Medicinal Chemistry |
Volume | 45 |
Numéro de publication | 8 |
Les DOIs | |
Etat de la publication | Publié - 1 août 2010 |
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Examiner les sujets de recherche de « Advantages of cocrystallization in the field of solid-statepharmaceutical chemistry: L-Proline and MnCl2 ». Ensemble, ils forment une empreinte digitale unique.Projets
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Etude physico-chimique et structurale du polymorphisme cristallin d'anticancéreux potentiels : la cocristallisation comme solution au problème de solubilité.
TILBORG, A. & Wouters, J.
1/10/09 → 30/09/13
Projet: Projet de thèse
Ensembles de données
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CCDC 757598: Experimental Crystal Structure Determination
Michaux, C. (Contributeur), NORBERG, B. (Contributeur), Tilborg, A. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2012
DOI: 10.5517/cctfbn6, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctfbn6&sid=DataCite
Ensemble de données