Study of cell responses to mitochondrial dysfunction: implications in the maintenance of mitochondrial biogenesis and apoptosis

ARNOULD, Thierry (PI)
Renard, Patricia (PI)
MERCY, Ludovic (Researcher)

Project: PHD

Project Details

Description

The study of mitobiogenesis in mtDNA-depleted cells will be done by 1) the investigation of the CaMKIV-CREB pathway as well as the determination of other transcription factors and co-activators 2) the study of mtCLIC in the generation of mitochondrial membrane potential and 3) the analysis of mtHSP70 phosphorylation in mitochondrial protein import.

Status	Finished
Effective start/end date	1/10/02 → 31/03/08

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Keywords

mtTFA
CREB
mtDNA depletion
protein import

1 Article

Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: Role for triglyceride content reduction
De Pauw, A., Demine, S., Tejerina Vargas, S. V., Dieu, M., Delaive, E., Kel, A., Renard, P., Raes, M. & Arnould, T., 1 May 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1123-41 19 p.
Research output: Contribution to journal › Article › peer-review

Study of cell responses to mitochondrial dysfunction: implications in the maintenance of mitochondrial biogenesis and apoptosis

Description

Keywords

Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: Role for triglyceride content reduction