Study of cell responses to mitochondrial dysfunction: implications in the maintenance of mitochondrial biogenesis and apoptosis

Project: PHD

Project Details

Description

The study of mitobiogenesis in mtDNA-depleted cells will be done by 1) the investigation of the CaMKIV-CREB pathway as well as the determination of other transcription factors and co-activators 2) the study of mtCLIC in the generation of mitochondrial membrane potential and 3) the analysis of mtHSP70 phosphorylation in mitochondrial protein import.
StatusFinished
Effective start/end date1/10/02 → 31/03/08
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Keywords

  • mtTFA
  • CREB
  • mtDNA depletion
  • protein import

Research Output

Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: Role for triglyceride content reduction

De Pauw, A., Demine, S., Tejerina Vargas, S. V., Dieu, M., Delaive, E., Kel, A., Renard, P., Raes, M. & Arnould, T., 1 May 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1123-41 19 p.

Research output: Contribution to journal › Article