Solvent-free synthesis and purification of poly[2-(dimethylamino)ethyl methacrylate] by atom transfer radical polymerization

Nadège Pantoustier, Sébastien Moins, Michaël Wautier, Philippe Degée, Philippe Dubois

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Solvent-free synthesis of well-defined poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) (co)polymers was performed by atom transfer radical polymerization conducted under very mild conditions (in bulk at 25 °C). The pH-dependence and the thermo-responsive behaviour of PDMAEMA in aqueous solution were operated to isolate and purify the (co)polymers without using any organic solvent or further catalyst extraction. The viscosity in aqueous solution of so-purified PDMAEMA homopolymers and their block copolymers with poly(ethylene glycol) (PEG) was studied as a function of molar mass and concentration and a typical polyelectrolyte behaviour was observed. these catalyst-deprived polycations are able to form stable and non toxic complexes with DNA, showing good transfection efficacies in gene therapy.

langue originaleAnglais
Pages (de - à)340-341
Nombre de pages2
journalChemical Communications
Volume3
Numéro de publication3
Les DOIs
Etat de la publicationPublié - 1 janv. 2003
Modification externeOui

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