Résultat de recherche par an
Résultat de recherche par an
Séverin Ronneau, Simon Moussa, Thibault Barbier, Raquel Conde-Álvarez, Amaia Zuniga-Ripa, Ignacio Moriyon, Jean-Jacques Letesson
Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs
Abstract The brucellae are α-Proteobacteria causing brucellosis, an important zoonosis. Although multiplying in endoplasmic reticulum-derived vacuoles, they cause no cell death, suggesting subtle but efficient use of host resources. Brucellae are amino-acid prototrophs able to grow with ammonium or use glutamate as the sole carbon-nitrogen source in vitro. They contain more than twice amino acid/peptide/polyamine uptake genes than the amino-acid auxotroph Legionella pneumophila, which multiplies in a similar vacuole, suggesting a different nutritional strategy. During these two last decades, many mutants of key actors in nitrogen metabolism (transporters, enzymes, regulators, etc.) have been described to be essential for full virulence of brucellae. Here, we review the genomic and experimental data on Brucella nitrogen metabolism and its connection with virulence. An analysis of various aspects of this metabolism (transport, assimilation, biosynthesis, catabolism, respiration and regulation) has highlighted differences and similarities in nitrogen metabolism with other α-Proteobacteria. Together, these data suggest that, during their intracellular life cycle, the brucellae use various nitrogen sources for biosynthesis, catabolism and respiration following a strategy that requires prototrophy and a tight regulation of nitrogen use.
langue originale | Anglais |
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Pages (de - à) | 1-19 |
Nombre de pages | 19 |
journal | Critical Reviews in Microbiology |
Les DOIs | |
Etat de la publication | Publié - 2014 |
Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs
Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs
LETESSON, J., Coenye, T., Van Dijck, P., Van Melderen, L., HOLS, P. & De Bolle, X.
1/10/12 → 30/09/17
Projet: Recherche
1/10/10 → 30/09/14
Projet: Projet de thèse
Xavier De Bolle (!!Manager)
Plateforme technologique Laboratoire de securite biologique au niveau 3Equipement/installations: Plateforme technolgique