Structural approach of human MAO-A using fold recognition (threading) techniques

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Abstract

The major goal of the present work is to further approach the structure of human monoamine oxidase A (MAO-A). A first partial three-dimensional model of human MAO-A has already been established using secondary structure predictions and fold recognition methods [Wouters and Baudoux, 1998]. In this modeled structure, a segment of the sequence (residues 369-393) located near the covalent linkage to the essential flavin cofactor, and potentially involved in the structure of the active site of the protein, could not be modeled. We here propose a possible fold for that segment, based on threading techniques. The identification of regions of the protein potentially involved in its dimerization was also undertaken by studying hydrophobic areas present at the surface of the structure.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalNeurobiology
Volume8
Issue number1
Publication statusPublished - 26 Sep 2000

Keywords

  • Flavoproteins
  • Fold prediction (threading)
  • Knowledge-based modeling
  • Membrane protein
  • Type A monoamine oxidase (MAO-A)

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