Sulfur-containing compounds, such as mercaptans, alkali sulfides, alkali sulfites, and alkali thiosulfates, are byproducts of industrial processes and pollutants of waste and natural waters. Other sulfur-containing compounds such as yperite are dangerous chemical weapons. Efficient photocatalytic decomposition of these molecules is a process that can find applications in emergency situations or for the controlled destruction of chemical warfare stockpiles. A series of heterogeneous photocatalysts consisting of a metal phthalocyanine or 2,4,6-triphenylpyrylium as photoactive components encapsulated inside the cavities of zeolite Y or the mesoporous channels of MCM-41 or supported on silica ortitania-silica was tested for the photocatalytic decomposition of yperite. Two types of photoreactors, either an open reactor naturally aerated or a closed quartz tube with a constant airflow using UV or visible ambient light, were used. These tests demonstrated that iron and manganese phthalocyanine and 2,4,6-triphenylpyrylium embedded in NaY ortitania-silica can be suitable solid photocatalysts for the degradation of yperite using UV and visible irradiation.