"self-repairing" nanoshell for cell protection

Nan Jiang, Xiao Yu Yang, Guo Liang Ying, Ling Shen, Jing Liu, Wei Geng, Ling Jun Dai, Shao Yin Liu, Jian Cao, Ge Tian, Tao Lei Sun, Shi Pu Li, Bao Lian Su

Research output: Contribution to journalArticlepeer-review


Self-repair is nature's way of protecting living organisms. However, most single cells are inherently less capable of self-repairing, which greatly limits their wide applications. Here, we present a self-assembly approach to create a nanoshell around the cell surface using nanoporous biohybrid aggregates. The biohybrid shells present self-repairing behaviour, resulting in high activity and extended viability of the encapsulated cells (eukaryotic and prokaryotic cells) in harsh micro-environments, such as under UV radiation, natural toxin invasion, high-light radiation and abrupt pH-value changes. Furthermore, an interaction mechanism is proposed and studied, which is successful to guide design and synthesis of self-repairing biohybrid shells using different bioactive molecules. This journal is

Original languageEnglish
Pages (from-to)486-491
Number of pages6
JournalChemical Science
Issue number1
Publication statusPublished - 1 Jan 2015


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