"self-repairing" nanoshell for cell protection

Nan Jiang, Xiao Yu Yang, Guo Liang Ying, Ling Shen, Jing Liu, Wei Geng, Ling Jun Dai, Shao Yin Liu, Jian Cao, Ge Tian, Tao Lei Sun, Shi Pu Li, Bao Lian Su

Research output: Contribution to journalArticle

Abstract

Self-repair is nature's way of protecting living organisms. However, most single cells are inherently less capable of self-repairing, which greatly limits their wide applications. Here, we present a self-assembly approach to create a nanoshell around the cell surface using nanoporous biohybrid aggregates. The biohybrid shells present self-repairing behaviour, resulting in high activity and extended viability of the encapsulated cells (eukaryotic and prokaryotic cells) in harsh micro-environments, such as under UV radiation, natural toxin invasion, high-light radiation and abrupt pH-value changes. Furthermore, an interaction mechanism is proposed and studied, which is successful to guide design and synthesis of self-repairing biohybrid shells using different bioactive molecules. This journal is

Original languageEnglish
Pages (from-to)486-491
Number of pages6
JournalChemical Science
Volume6
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015

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Nanoshells
Ultraviolet radiation
Self assembly
Repair
Radiation
Molecules

Cite this

Jiang, Nan ; Yang, Xiao Yu ; Ying, Guo Liang ; Shen, Ling ; Liu, Jing ; Geng, Wei ; Dai, Ling Jun ; Liu, Shao Yin ; Cao, Jian ; Tian, Ge ; Sun, Tao Lei ; Li, Shi Pu ; Su, Bao Lian. / "self-repairing" nanoshell for cell protection. In: Chemical Science. 2015 ; Vol. 6, No. 1. pp. 486-491.
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Jiang, N, Yang, XY, Ying, GL, Shen, L, Liu, J, Geng, W, Dai, LJ, Liu, SY, Cao, J, Tian, G, Sun, TL, Li, SP & Su, BL 2015, '"self-repairing" nanoshell for cell protection' Chemical Science, vol. 6, no. 1, pp. 486-491. https://doi.org/10.1039/c4sc02638a

"self-repairing" nanoshell for cell protection. / Jiang, Nan; Yang, Xiao Yu; Ying, Guo Liang; Shen, Ling; Liu, Jing; Geng, Wei; Dai, Ling Jun; Liu, Shao Yin; Cao, Jian; Tian, Ge; Sun, Tao Lei; Li, Shi Pu; Su, Bao Lian.

In: Chemical Science, Vol. 6, No. 1, 01.01.2015, p. 486-491.

Research output: Contribution to journalArticle

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AU - Geng, Wei

AU - Dai, Ling Jun

AU - Liu, Shao Yin

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AU - Tian, Ge

AU - Sun, Tao Lei

AU - Li, Shi Pu

AU - Su, Bao Lian

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Jiang N, Yang XY, Ying GL, Shen L, Liu J, Geng W et al. "self-repairing" nanoshell for cell protection. Chemical Science. 2015 Jan 1;6(1):486-491. https://doi.org/10.1039/c4sc02638a