TY - JOUR
T1 - Radiobiological risks following dentomaxillofacial imaging
T2 - Should we be concerned?
AU - Belmans, Niels
AU - Oenning, Anne Caroline
AU - Salmon, Benjamin
AU - Baselet, Bjorn
AU - Tabury, Kevin
AU - Lucas, Stéphane
AU - Lambrichts, Ivo
AU - Moreels, Marjan
AU - Jacobs, Reinhilde
AU - Baatout, Sarah
N1 - Funding Information:
This work was supported by the European Atomic Energy Community’s Seventh Framework Programme FP7/2007–2011 under grant agreement No. 604984 (OPERRA: Open Project for the European Radiation Research Area) and by the Research Foundation – Flanders (FWO) under grant agreement No. G0A09.18N (TREASURE: Follow up of radiation dose and radiobiological effects after dental exposure to radiation). N. Belmans is supported by a doctoral SCK CEN grant.
Publisher Copyright:
© 2021 The Authors.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Objectives: This review aimed to present studies that prospectively investigated biological effects in patients following diagnostic dentomaxillofacial radiology (DMFR). Methods: Literature was systematically searched to retrieve all studies assessing radiobiological effects of using X-ray imaging in the dentomaxillofacial area, with reference to radiobiological outcomes for other imaging modalities and fields. Results: There is a lot of variability in the reported radiobiological assessment methods and radiation dose measures, making comparisons of radiobiological studies challenging. Most radiological DMFR studies are focusing on genotoxicity and cytotoxicity, data for 2D dentomaxillofacial radiographs, albeit with some methodological weakness biasing the results. For CBCT, available evidence is limited and few studies include comparative data on both adults and children. Conclusions In the future, one will have to strive towards patient-specific measures by considering age, gender and other individual radiation sensitivity-related factors. Ultimately, future radioprotection strategies should build further on the concept of personalized medicine, with patient-specific optimization of the imaging protocol, based on radiobiological variables.
AB - Objectives: This review aimed to present studies that prospectively investigated biological effects in patients following diagnostic dentomaxillofacial radiology (DMFR). Methods: Literature was systematically searched to retrieve all studies assessing radiobiological effects of using X-ray imaging in the dentomaxillofacial area, with reference to radiobiological outcomes for other imaging modalities and fields. Results: There is a lot of variability in the reported radiobiological assessment methods and radiation dose measures, making comparisons of radiobiological studies challenging. Most radiological DMFR studies are focusing on genotoxicity and cytotoxicity, data for 2D dentomaxillofacial radiographs, albeit with some methodological weakness biasing the results. For CBCT, available evidence is limited and few studies include comparative data on both adults and children. Conclusions In the future, one will have to strive towards patient-specific measures by considering age, gender and other individual radiation sensitivity-related factors. Ultimately, future radioprotection strategies should build further on the concept of personalized medicine, with patient-specific optimization of the imaging protocol, based on radiobiological variables.
KW - Cytotoxicity
KW - Dentomaxillofacial imaging radiation risk
KW - Genotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85113542939&partnerID=8YFLogxK
U2 - 10.1259/dmfr.20210153
DO - 10.1259/dmfr.20210153
M3 - Review article
C2 - 33989056
AN - SCOPUS:85113542939
SN - 0250-832X
VL - 50
JO - Dentomaxillofacial Radiology
JF - Dentomaxillofacial Radiology
IS - 6
M1 - 20210153
ER -