TY - JOUR
T1 - Novel results on the biocyclisation of 2,3-oxidosqualene analogs by sterol cyclase
AU - Krief, A.
AU - Pasau, P.
AU - Guittet, E.
AU - Shan, Y.Y.
AU - Herin, M.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Although Oxidosqualenes analogs bearing a E-Δ C,C double bond are cyclized by 2,3-oxidosqualene cyclase (EC 5.4.99.7, 'sterol cyclase') to produce 20-R norlanosterols, those possessing a Z-Δ C,C double bond instead produce, a mixture of 20-S norlanosterols and tricyclic derivatives whose ratio depends upon the length of the side chain.
AB - Although Oxidosqualenes analogs bearing a E-Δ C,C double bond are cyclized by 2,3-oxidosqualene cyclase (EC 5.4.99.7, 'sterol cyclase') to produce 20-R norlanosterols, those possessing a Z-Δ C,C double bond instead produce, a mixture of 20-S norlanosterols and tricyclic derivatives whose ratio depends upon the length of the side chain.
UR - http://www.scopus.com/inward/record.url?scp=0027465478&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(01)80913-6
DO - 10.1016/S0960-894X(01)80913-6
M3 - Article
AN - SCOPUS:0027465478
SN - 0960-894X
VL - 3
SP - 365
EP - 368
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 2
ER -