Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model

Alain Nchimi, Audrey Courtois, Mounia El Hachemi, Ziad Touat, Pierre Drion, Nadia Withofs, Geoff Warnock, Mohamed Ali Bahri, Jean-Michel Dogne, Jean Paul Cheramy-Bien, Laurent Schoysman, Julien Joskin, Jean Baptiste Michel, Jean Olivier Defraigne, Alain Plenevaux, Natzi Sakalihasan

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods: The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results: All of the following significantly increased with time post-induction (p <0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion: Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. Key Points: • ILT occurrence in AAA is associated with increasing FDG uptake and growth. • MRI signalling changes in ILT reflect activities such as haemorrhage and RBC trapping. • Monitoring ILT activities using MRI may require no exogenous contrast agent.

Original languageEnglish
Pages (from-to)2378-2386
Number of pages9
JournalEuropean Radiology
Volume26
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016

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Abdominal Aortic Aneurysm
Thrombosis
Growth
Deoxyglucose
Magnetic Resonance Imaging
Positron-Emission Tomography
Pancreatic Elastase
Ambulatory Surgical Procedures
Aneurysm
Iron
X-Ray Microtomography
Contrast Media
Histology
Logistic Models
Hemorrhage

Keywords

  • Aneurysm
  • Aorta
  • Imaging
  • Iron
  • Thrombus

Cite this

Nchimi, Alain ; Courtois, Audrey ; El Hachemi, Mounia ; Touat, Ziad ; Drion, Pierre ; Withofs, Nadia ; Warnock, Geoff ; Bahri, Mohamed Ali ; Dogne, Jean-Michel ; Cheramy-Bien, Jean Paul ; Schoysman, Laurent ; Joskin, Julien ; Michel, Jean Baptiste ; Defraigne, Jean Olivier ; Plenevaux, Alain ; Sakalihasan, Natzi. / Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model. In: European Radiology. 2016 ; Vol. 26, No. 7. pp. 2378-2386.
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abstract = "Objectives: To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods: The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results: All of the following significantly increased with time post-induction (p <0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion: Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. Key Points: • ILT occurrence in AAA is associated with increasing FDG uptake and growth. • MRI signalling changes in ILT reflect activities such as haemorrhage and RBC trapping. • Monitoring ILT activities using MRI may require no exogenous contrast agent.",
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Nchimi, A, Courtois, A, El Hachemi, M, Touat, Z, Drion, P, Withofs, N, Warnock, G, Bahri, MA, Dogne, J-M, Cheramy-Bien, JP, Schoysman, L, Joskin, J, Michel, JB, Defraigne, JO, Plenevaux, A & Sakalihasan, N 2016, 'Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model', European Radiology, vol. 26, no. 7, pp. 2378-2386. https://doi.org/10.1007/s00330-015-4010-y

Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model. / Nchimi, Alain; Courtois, Audrey; El Hachemi, Mounia; Touat, Ziad; Drion, Pierre; Withofs, Nadia; Warnock, Geoff; Bahri, Mohamed Ali; Dogne, Jean-Michel; Cheramy-Bien, Jean Paul; Schoysman, Laurent; Joskin, Julien; Michel, Jean Baptiste; Defraigne, Jean Olivier; Plenevaux, Alain; Sakalihasan, Natzi.

In: European Radiology, Vol. 26, No. 7, 01.07.2016, p. 2378-2386.

Research output: Contribution to journalArticle

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T1 - Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model

AU - Nchimi, Alain

AU - Courtois, Audrey

AU - El Hachemi, Mounia

AU - Touat, Ziad

AU - Drion, Pierre

AU - Withofs, Nadia

AU - Warnock, Geoff

AU - Bahri, Mohamed Ali

AU - Dogne, Jean-Michel

AU - Cheramy-Bien, Jean Paul

AU - Schoysman, Laurent

AU - Joskin, Julien

AU - Michel, Jean Baptiste

AU - Defraigne, Jean Olivier

AU - Plenevaux, Alain

AU - Sakalihasan, Natzi

PY - 2016/7/1

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N2 - Objectives: To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods: The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results: All of the following significantly increased with time post-induction (p <0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion: Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. Key Points: • ILT occurrence in AAA is associated with increasing FDG uptake and growth. • MRI signalling changes in ILT reflect activities such as haemorrhage and RBC trapping. • Monitoring ILT activities using MRI may require no exogenous contrast agent.

AB - Objectives: To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods: The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results: All of the following significantly increased with time post-induction (p <0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion: Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. Key Points: • ILT occurrence in AAA is associated with increasing FDG uptake and growth. • MRI signalling changes in ILT reflect activities such as haemorrhage and RBC trapping. • Monitoring ILT activities using MRI may require no exogenous contrast agent.

KW - Aneurysm

KW - Aorta

KW - Imaging

KW - Iron

KW - Thrombus

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