Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

A. Carpentier, P.-Y. Barez, M. Hamaïdia, H. Gazon, Alix de Brogniez, S. Perike, N. Gillet, L. Willems

Research output: Contribution to journalArticlepeer-review

Abstract

[en] Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes\ncer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly\associated myelopathy---tropical spastic paraparesis, HAM/TSP). Since virions are\particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying\an integrated provirus. After transcription, the viral genomic RNA undergoes reverse\transcription and integration into the chromosomal DNA of a cell from the newly infected\ The virus then replicates by either one of two modes: (i) an infectious cycle by virus\budding and infection of new targets and (ii) mitotic division of cells harboring an integrated\ HTLV-1 replication initiates a series of mechanisms in the host including antiviral\immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to\unteract these defense mechanisms allowing continuous persistence in humans.
Original languageEnglish
Pages (from-to)3603-3624
Number of pages22
JournalViruses
Volume7
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Sciences de la santé humaine => Oncologie
  • HTLV-1
  • viral replication
  • viral persistence
  • Tax
  • HBZ

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