Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

A. Carpentier; P.-Y. Barez; M. Hamaïdia; H. Gazon; Alix de Brogniez; S. Perike; N. Gillet; L. Willems

doi:10.3390/v7072793

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

A. Carpentier, P.-Y. Barez, M. Hamaïdia, H. Gazon, Alix de Brogniez, S. Perike, N. Gillet, L. Willems

Research output: Contribution to journal › Article › peer-review

Abstract

[en] Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes\ncer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly\associated myelopathy---tropical spastic paraparesis, HAM/TSP). Since virions are\particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying\an integrated provirus. After transcription, the viral genomic RNA undergoes reverse\transcription and integration into the chromosomal DNA of a cell from the newly infected\ The virus then replicates by either one of two modes: (i) an infectious cycle by virus\budding and infection of new targets and (ii) mitotic division of cells harboring an integrated\ HTLV-1 replication initiates a series of mechanisms in the host including antiviral\immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to\unteract these defense mechanisms allowing continuous persistence in humans.

Original language	English
Pages (from-to)	3603-3624
Number of pages	22
Journal	Viruses
Volume	7
DOIs	https://doi.org/10.3390/v7072793
Publication status	Published - 2015
Externally published	Yes

Keywords

Sciences de la santé humaine => Oncologie
HTLV-1
viral replication
viral persistence
Tax
HBZ

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/v7072793

http://hdl.handle.net/2268/183778; http://www.mdpi.com/1999-4915/7/7/2793

Cite this

@article{c74731150a424ba7a9eb8615d0e38435,

title = "Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence",

abstract = "[en] Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes\ncer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly\associated myelopathy---tropical spastic paraparesis, HAM/TSP). Since virions are\particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying\an integrated provirus. After transcription, the viral genomic RNA undergoes reverse\transcription and integration into the chromosomal DNA of a cell from the newly infected\ The virus then replicates by either one of two modes: (i) an infectious cycle by virus\budding and infection of new targets and (ii) mitotic division of cells harboring an integrated\ HTLV-1 replication initiates a series of mechanisms in the host including antiviral\immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to\unteract these defense mechanisms allowing continuous persistence in humans.",

keywords = "Sciences de la sant{\'e} humaine => Oncologie, HTLV-1, viral replication, viral persistence, Tax, HBZ",

author = "A. Carpentier and P.-Y. Barez and M. Hama{\"i}dia and H. Gazon and Brogniez, {Alix de} and S. Perike and N. Gillet and L. Willems",

year = "2015",

doi = "10.3390/v7072793",

language = "English",

volume = "7",

pages = "3603--3624",

journal = "Viruses",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

}

TY - JOUR

T1 - Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

AU - Carpentier, A.

AU - Barez, P.-Y.

AU - Hamaïdia, M.

AU - Gazon, H.

AU - Brogniez, Alix de

AU - Perike, S.

AU - Gillet, N.

AU - Willems, L.

PY - 2015

Y1 - 2015

N2 - [en] Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes\ncer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly\associated myelopathy---tropical spastic paraparesis, HAM/TSP). Since virions are\particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying\an integrated provirus. After transcription, the viral genomic RNA undergoes reverse\transcription and integration into the chromosomal DNA of a cell from the newly infected\ The virus then replicates by either one of two modes: (i) an infectious cycle by virus\budding and infection of new targets and (ii) mitotic division of cells harboring an integrated\ HTLV-1 replication initiates a series of mechanisms in the host including antiviral\immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to\unteract these defense mechanisms allowing continuous persistence in humans.

AB - [en] Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes\ncer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly\associated myelopathy---tropical spastic paraparesis, HAM/TSP). Since virions are\particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying\an integrated provirus. After transcription, the viral genomic RNA undergoes reverse\transcription and integration into the chromosomal DNA of a cell from the newly infected\ The virus then replicates by either one of two modes: (i) an infectious cycle by virus\budding and infection of new targets and (ii) mitotic division of cells harboring an integrated\ HTLV-1 replication initiates a series of mechanisms in the host including antiviral\immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to\unteract these defense mechanisms allowing continuous persistence in humans.

KW - Sciences de la santé humaine => Oncologie

KW - HTLV-1

KW - viral replication

KW - viral persistence

KW - Tax

KW - HBZ

U2 - 10.3390/v7072793

DO - 10.3390/v7072793

M3 - Article

VL - 7

SP - 3603

EP - 3624

JO - Viruses

JF - Viruses

ER -

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this