TY - JOUR
T1 - Mitochondrial Uncoupling
T2 - A Key Controller of Biological Processes in Physiology and Diseases
AU - Stéphane Demine
AU - Renard, Patricia
AU - Arnould, Thierry
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2019/7/30
Y1 - 2019/7/30
N2 - Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis. Although this process was originally considered a mitochondrial dysfunction, the identification of UCP-1 as an endogenous physiological uncoupling protein suggests that the process could be involved in many other biological processes. In this review, we first compare the mitochondrial uncoupling agents available in term of mechanistic and non-specific effects. Proteins regulating mitochondrial uncoupling, as well as chemical compounds with uncoupling properties are discussed. Second, we summarize the most recent findings linking mitochondrial uncoupling and other cellular or biological processes, such as bulk and specific autophagy, reactive oxygen species production, protein secretion, cell death, physical exercise, metabolic adaptations in adipose tissue, and cell signaling. Finally, we show how mitochondrial uncoupling could be used to treat several human diseases, such as obesity, cardiovascular diseases, or neurological disorders.
AB - Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis. Although this process was originally considered a mitochondrial dysfunction, the identification of UCP-1 as an endogenous physiological uncoupling protein suggests that the process could be involved in many other biological processes. In this review, we first compare the mitochondrial uncoupling agents available in term of mechanistic and non-specific effects. Proteins regulating mitochondrial uncoupling, as well as chemical compounds with uncoupling properties are discussed. Second, we summarize the most recent findings linking mitochondrial uncoupling and other cellular or biological processes, such as bulk and specific autophagy, reactive oxygen species production, protein secretion, cell death, physical exercise, metabolic adaptations in adipose tissue, and cell signaling. Finally, we show how mitochondrial uncoupling could be used to treat several human diseases, such as obesity, cardiovascular diseases, or neurological disorders.
KW - adipocyte browning
KW - apoptosis
KW - autophagy
KW - cell death
KW - cell signaling
KW - mitochondrial uncoupling
KW - oxidative stress
KW - physical exercise
KW - protein secretion
KW - uncoupler
UR - https://susy.mdpi.com/user/manuscripts/review_info/eb89ce77d313418a61ae21e33ae82188
UR - http://www.scopus.com/inward/record.url?scp=85074871924&partnerID=8YFLogxK
U2 - 10.3390/cells8080795
DO - 10.3390/cells8080795
M3 - Review article
C2 - 31366145
VL - 8
SP - 795
EP - 838
JO - Cells
JF - Cells
SN - 2073-4409
IS - 8
M1 - cells-08-00795
ER -