Learning a Bimanual Cooperative Skill in Chronic Stroke Under Noninvasive Brain Stimulation

A Randomized Controlled Trial

Maral Yeganeh Doost, Jean-Jacques Orban de Xivry, Benoît Herman, Léna Vanthournhout, Audrey Riga, Benoît Bihin, Jacques Jamart, Patrice Laloux, Jean-Marc Raymackers, Yves Vandermeeren

Research output: Contribution to journalArticle

Abstract

Background. Transcranial direct current stimulation (tDCS) has been suggested to improve poststroke recovery. However, its effects on bimanual motor learning after stroke have not previously been explored. Objective. We investigated whether dual-tDCS of the primary motor cortex (M1), with cathodal and anodal tDCS applied over undamaged and damaged hemispheres, respectively, improves learning and retention of a new bimanual cooperative motor skill in stroke patients. Method. Twenty-one chronic hemiparetic patients were recruited for a randomized, double-blinded, cross-over, sham-controlled trial. While receiving real or sham dual-tDCS, they trained on a bimanual cooperative task called CIRCUIT. Changes in performance were quantified via bimanual speed/accuracy trade-off (Bi-SAT) and bimanual coordination factor (Bi-Co) before, during, and 0, 30, and 60 minutes after dual-tDCS, as well as one week later to measure retention. A generalization test then followed, where patients were asked to complete a new CIRCUIT layout. Results. The patients were able to learn and retain the bimanual cooperative skill. However, a general linear mixed model did not detect a significant difference in retention between the real and sham dual-tDCS conditions for either Bi-SAT or Bi-Co. Similarly, no difference in generalization was detected for Bi-SAT or Bi-Co. Conclusion. The chronic hemiparetic stroke patients learned and retained the complex bimanual cooperative task and generalized the newly acquired skills to other tasks, indicating that bimanual CIRCUIT training is promising as a neurorehabilitation approach. However, bimanual motor skill learning was not enhanced by dual-tDCS in these patients.

Original languageEnglish
Pages (from-to)486-498
Number of pages13
JournalNeurorehabilitation and Neural Repair
Volume33
Issue number6
DOIs
Publication statusPublished - 15 May 2019

Fingerprint

Randomized Controlled Trials
Stroke
Learning
Brain
Motor Skills
Motor Cortex
Transcranial Direct Current Stimulation
Linear Models

Keywords

  • motor skill learning
  • bimanual coordination
  • stroke
  • neurohabilitation
  • tDCS
  • Noninvasive brain stimulation
  • neurorehabilitation
  • noninvasive brain stimulation

Cite this

Doost, Maral Yeganeh ; Orban de Xivry, Jean-Jacques ; Herman, Benoît ; Vanthournhout, Léna ; Riga, Audrey ; Bihin, Benoît ; Jamart, Jacques ; Laloux, Patrice ; Raymackers, Jean-Marc ; Vandermeeren, Yves. / Learning a Bimanual Cooperative Skill in Chronic Stroke Under Noninvasive Brain Stimulation : A Randomized Controlled Trial. In: Neurorehabilitation and Neural Repair. 2019 ; Vol. 33, No. 6. pp. 486-498.
@article{4dc42713524448fc9ee6d9568d4d1ce3,
title = "Learning a Bimanual Cooperative Skill in Chronic Stroke Under Noninvasive Brain Stimulation: A Randomized Controlled Trial",
abstract = "Background. Transcranial direct current stimulation (tDCS) has been suggested to improve poststroke recovery. However, its effects on bimanual motor learning after stroke have not previously been explored. Objective. We investigated whether dual-tDCS of the primary motor cortex (M1), with cathodal and anodal tDCS applied over undamaged and damaged hemispheres, respectively, improves learning and retention of a new bimanual cooperative motor skill in stroke patients. Method. Twenty-one chronic hemiparetic patients were recruited for a randomized, double-blinded, cross-over, sham-controlled trial. While receiving real or sham dual-tDCS, they trained on a bimanual cooperative task called CIRCUIT. Changes in performance were quantified via bimanual speed/accuracy trade-off (Bi-SAT) and bimanual coordination factor (Bi-Co) before, during, and 0, 30, and 60 minutes after dual-tDCS, as well as one week later to measure retention. A generalization test then followed, where patients were asked to complete a new CIRCUIT layout. Results. The patients were able to learn and retain the bimanual cooperative skill. However, a general linear mixed model did not detect a significant difference in retention between the real and sham dual-tDCS conditions for either Bi-SAT or Bi-Co. Similarly, no difference in generalization was detected for Bi-SAT or Bi-Co. Conclusion. The chronic hemiparetic stroke patients learned and retained the complex bimanual cooperative task and generalized the newly acquired skills to other tasks, indicating that bimanual CIRCUIT training is promising as a neurorehabilitation approach. However, bimanual motor skill learning was not enhanced by dual-tDCS in these patients.",
keywords = "motor skill learning, bimanual coordination, stroke, neurohabilitation, tDCS, Noninvasive brain stimulation, neurorehabilitation, noninvasive brain stimulation",
author = "Doost, {Maral Yeganeh} and {Orban de Xivry}, Jean-Jacques and Beno{\^i}t Herman and L{\'e}na Vanthournhout and Audrey Riga and Beno{\^i}t Bihin and Jacques Jamart and Patrice Laloux and Jean-Marc Raymackers and Yves Vandermeeren",
year = "2019",
month = "5",
day = "15",
doi = "10.1177/1545968319847963",
language = "English",
volume = "33",
pages = "486--498",
journal = "Neurorehabilitation and Neural Repair",
issn = "1545-9683",
publisher = "Sage Publications",
number = "6",

}

Learning a Bimanual Cooperative Skill in Chronic Stroke Under Noninvasive Brain Stimulation : A Randomized Controlled Trial. / Doost, Maral Yeganeh; Orban de Xivry, Jean-Jacques; Herman, Benoît; Vanthournhout, Léna; Riga, Audrey; Bihin, Benoît; Jamart, Jacques; Laloux, Patrice; Raymackers, Jean-Marc; Vandermeeren, Yves.

In: Neurorehabilitation and Neural Repair, Vol. 33, No. 6, 15.05.2019, p. 486-498.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Learning a Bimanual Cooperative Skill in Chronic Stroke Under Noninvasive Brain Stimulation

T2 - A Randomized Controlled Trial

AU - Doost, Maral Yeganeh

AU - Orban de Xivry, Jean-Jacques

AU - Herman, Benoît

AU - Vanthournhout, Léna

AU - Riga, Audrey

AU - Bihin, Benoît

AU - Jamart, Jacques

AU - Laloux, Patrice

AU - Raymackers, Jean-Marc

AU - Vandermeeren, Yves

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Background. Transcranial direct current stimulation (tDCS) has been suggested to improve poststroke recovery. However, its effects on bimanual motor learning after stroke have not previously been explored. Objective. We investigated whether dual-tDCS of the primary motor cortex (M1), with cathodal and anodal tDCS applied over undamaged and damaged hemispheres, respectively, improves learning and retention of a new bimanual cooperative motor skill in stroke patients. Method. Twenty-one chronic hemiparetic patients were recruited for a randomized, double-blinded, cross-over, sham-controlled trial. While receiving real or sham dual-tDCS, they trained on a bimanual cooperative task called CIRCUIT. Changes in performance were quantified via bimanual speed/accuracy trade-off (Bi-SAT) and bimanual coordination factor (Bi-Co) before, during, and 0, 30, and 60 minutes after dual-tDCS, as well as one week later to measure retention. A generalization test then followed, where patients were asked to complete a new CIRCUIT layout. Results. The patients were able to learn and retain the bimanual cooperative skill. However, a general linear mixed model did not detect a significant difference in retention between the real and sham dual-tDCS conditions for either Bi-SAT or Bi-Co. Similarly, no difference in generalization was detected for Bi-SAT or Bi-Co. Conclusion. The chronic hemiparetic stroke patients learned and retained the complex bimanual cooperative task and generalized the newly acquired skills to other tasks, indicating that bimanual CIRCUIT training is promising as a neurorehabilitation approach. However, bimanual motor skill learning was not enhanced by dual-tDCS in these patients.

AB - Background. Transcranial direct current stimulation (tDCS) has been suggested to improve poststroke recovery. However, its effects on bimanual motor learning after stroke have not previously been explored. Objective. We investigated whether dual-tDCS of the primary motor cortex (M1), with cathodal and anodal tDCS applied over undamaged and damaged hemispheres, respectively, improves learning and retention of a new bimanual cooperative motor skill in stroke patients. Method. Twenty-one chronic hemiparetic patients were recruited for a randomized, double-blinded, cross-over, sham-controlled trial. While receiving real or sham dual-tDCS, they trained on a bimanual cooperative task called CIRCUIT. Changes in performance were quantified via bimanual speed/accuracy trade-off (Bi-SAT) and bimanual coordination factor (Bi-Co) before, during, and 0, 30, and 60 minutes after dual-tDCS, as well as one week later to measure retention. A generalization test then followed, where patients were asked to complete a new CIRCUIT layout. Results. The patients were able to learn and retain the bimanual cooperative skill. However, a general linear mixed model did not detect a significant difference in retention between the real and sham dual-tDCS conditions for either Bi-SAT or Bi-Co. Similarly, no difference in generalization was detected for Bi-SAT or Bi-Co. Conclusion. The chronic hemiparetic stroke patients learned and retained the complex bimanual cooperative task and generalized the newly acquired skills to other tasks, indicating that bimanual CIRCUIT training is promising as a neurorehabilitation approach. However, bimanual motor skill learning was not enhanced by dual-tDCS in these patients.

KW - motor skill learning

KW - bimanual coordination

KW - stroke

KW - neurohabilitation

KW - tDCS

KW - Noninvasive brain stimulation

KW - neurorehabilitation

KW - noninvasive brain stimulation

UR - http://journals.sagepub.com/doi/10.1177/1545968319847963

UR - http://www.mendeley.com/research/learning-bimanual-cooperative-skill-chronic-stroke-under-noninvasive-brain-stimulation-randomized-co

UR - http://www.scopus.com/inward/record.url?scp=85066841833&partnerID=8YFLogxK

U2 - 10.1177/1545968319847963

DO - 10.1177/1545968319847963

M3 - Article

VL - 33

SP - 486

EP - 498

JO - Neurorehabilitation and Neural Repair

JF - Neurorehabilitation and Neural Repair

SN - 1545-9683

IS - 6

ER -