Indistinguishability analysis and observer design for size-structured cell populations

P. Jerono, J. J. Winkin, A. Vande Wouwer, A. Schaum

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Abstract

The observability property of population balance equations with biomass measurements is addressed within the framework of indistinguishable trajectories. The population balance equation is described by a partial integro-differential equation which is coupled with an ordinary differential equation for the nutrient dynamics. For the semi-discretized model equations, the dynamics of indistinguishable trajectories are derived and evaluated for the special case of equal partitioning at cell division revealing that the observability property is guaranteed as long as the nutrient concentration is not depleted. Based on these results, an observer is designed and tested in simulation to estimate the cell population distribution using biomass measurements in a batch bioreactor for the case of a bi-structured population.

Original languageEnglish
Title of host publicationIFAC-PapersOnLine
EditorsHideaki Ishii, Yoshio Ebihara, Jun-ichi Imura, Masaki Yamakita
PublisherElsevier
Pages581-586
Number of pages6
Edition2
ISBN (Electronic)9781713872344
DOIs
Publication statusPublished - 1 Jul 2023
Event22nd IFAC World Congress - Yokohama, Japan
Duration: 9 Jul 202314 Jul 2023

Publication series

NameIFAC-PapersOnLine
PublisherIFAC Secretariat
ISSN (Print)2405-8963

Conference

Conference22nd IFAC World Congress
Country/TerritoryJapan
CityYokohama
Period9/07/2314/07/23

Keywords

  • cell population dynamics
  • indistinguishable trajectories
  • Observability

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