Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area

Christina Schmidt; Fabienne Collette; Yves Leclercq; Virginie Sterpenich; Gilles Vandewalle; Pierre Berthomier; Christian Berthomier; Christophe Phillips; Gilberte Tinguely; Annabelle Darsaud; Steffen Gais; Manuel Schabus; Martin Desseilles; Thien Thanh Dang-Vu; Eric Salmon; Evelyne Balteau; Christian Degueldre; André Luxen; Pierre Maquet; Christian Cajochen; Philippe Peigneux

doi:10.1126/science.1167337

Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area

Christina Schmidt, Fabienne Collette, Yves Leclercq, Virginie Sterpenich, Gilles Vandewalle, Pierre Berthomier, Christian Berthomier, Christophe Phillips, Gilberte Tinguely, Annabelle Darsaud, Steffen Gais, Manuel Schabus, Martin Desseilles, Thien Thanh Dang-Vu, Eric Salmon, Evelyne Balteau, Christian Degueldre, André Luxen, Pierre Maquet, Christian CajochenPhilippe Peigneux

Research output: Contribution to journal › Article › peer-review

Abstract

Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.

Original language	English
Pages (from-to)	516-9
Number of pages	4
Journal	Science (New York, N.Y.)
Volume	324
Issue number	5926
DOIs	https://doi.org/10.1126/science.1167337
Publication status	Published - 24 Apr 2009

Keywords

Attention
Brain Mapping
Circadian Rhythm
Cognition
Female
Homeostasis
Humans
Magnetic Resonance Imaging
Male
Melatonin
Polysomnography
Psychomotor Performance
Sleep
Suprachiasmatic Nucleus
Thalamus
Wakefulness
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1167337

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Schmidt, C., Collette, F., Leclercq, Y., Sterpenich, V., Vandewalle, G., Berthomier, P., Berthomier, C., Phillips, C., Tinguely, G., Darsaud, A., Gais, S., Schabus, M., Desseilles, M., Dang-Vu, T. T., Salmon, E., Balteau, E., Degueldre, C., Luxen, A., Maquet, P., ... Peigneux, P. (2009). Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Science (New York, N.Y.), 324(5926), 516-9. https://doi.org/10.1126/science.1167337

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title = "Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area",

abstract = "Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.",

keywords = "Attention, Brain Mapping, Circadian Rhythm, Cognition, Female, Homeostasis, Humans, Magnetic Resonance Imaging, Male, Melatonin, Polysomnography, Psychomotor Performance, Sleep, Suprachiasmatic Nucleus, Thalamus, Wakefulness, Young Adult",

author = "Christina Schmidt and Fabienne Collette and Yves Leclercq and Virginie Sterpenich and Gilles Vandewalle and Pierre Berthomier and Christian Berthomier and Christophe Phillips and Gilberte Tinguely and Annabelle Darsaud and Steffen Gais and Manuel Schabus and Martin Desseilles and Dang-Vu, {Thien Thanh} and Eric Salmon and Evelyne Balteau and Christian Degueldre and Andr{\'e} Luxen and Pierre Maquet and Christian Cajochen and Philippe Peigneux",

year = "2009",

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doi = "10.1126/science.1167337",

language = "English",

volume = "324",

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Schmidt, C, Collette, F, Leclercq, Y, Sterpenich, V, Vandewalle, G, Berthomier, P, Berthomier, C, Phillips, C, Tinguely, G, Darsaud, A, Gais, S, Schabus, M, Desseilles, M, Dang-Vu, TT, Salmon, E, Balteau, E, Degueldre, C, Luxen, A, Maquet, P, Cajochen, C & Peigneux, P 2009, 'Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area', Science (New York, N.Y.), vol. 324, no. 5926, pp. 516-9. https://doi.org/10.1126/science.1167337

TY - JOUR

T1 - Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area

AU - Schmidt, Christina

AU - Collette, Fabienne

AU - Leclercq, Yves

AU - Sterpenich, Virginie

AU - Vandewalle, Gilles

AU - Berthomier, Pierre

AU - Berthomier, Christian

AU - Phillips, Christophe

AU - Tinguely, Gilberte

AU - Darsaud, Annabelle

AU - Gais, Steffen

AU - Schabus, Manuel

AU - Desseilles, Martin

AU - Dang-Vu, Thien Thanh

AU - Salmon, Eric

AU - Balteau, Evelyne

AU - Degueldre, Christian

AU - Luxen, André

AU - Maquet, Pierre

AU - Cajochen, Christian

AU - Peigneux, Philippe

PY - 2009/4/24

Y1 - 2009/4/24

N2 - Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.

AB - Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.

KW - Attention

KW - Brain Mapping

KW - Circadian Rhythm

KW - Cognition

KW - Female

KW - Homeostasis

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Melatonin

KW - Polysomnography

KW - Psychomotor Performance

KW - Sleep

KW - Suprachiasmatic Nucleus

KW - Thalamus

KW - Wakefulness

KW - Young Adult

U2 - 10.1126/science.1167337

DO - 10.1126/science.1167337

M3 - Article

C2 - 19390047

SN - 1095-9203

VL - 324

SP - 516

EP - 519

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

IS - 5926

ER -

Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area

Abstract

Keywords

UN SDGs

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