Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs

Philippe Kolh, Bernard Lambermont, Alexandre Ghuysen, Vincent Tchana-Sato, Jean-Michel Dogne, Julien Hanson, Paul Gerard, Vincent D'Orio, Luc Pierard, Raymond Limet

Research output: Contribution to journalArticle

Abstract

This study investigated the effects of dobutamine on left ventriculoarterial (VA) coupling and mechanical efficiency in acutely ischemic pigs. Experiments were performed in 12 pigs in which vascular properties, including peripheral resistance (R2), compliance (C), and arterial elastance (Ea), were estimated with a windkessel model, and left ventricular (LV) function by the slope (Ees) of the end-systolic pressure-volume relationship (ESPVR) and stroke work (SW). VA coupling was defined as Ees/Ea, and mechanical efficiency as SW/pressure-volume area (PVA). In all animals, the left anterior descending coronary artery was ligated after basal measures. The animals were then randomly divided into 2 groups: group CTRL (n = 6) was followed for 180 minutes without other intervention, whereas group DOBU (n = 6) was infused with dobutamine (5 microg x kg(-1) x min(-1)) starting after T60 measures. Coronary occlusion induced a rightward shift of ESPVR and a decrease in Ees from 3.67 +/- 0.33 to 1.92 +/- 0.20 mm Hg x mL(-1), while Ea changed from 3.33 +/- 0.56 to 4.65 +/- 0.29 mm Hg x mL, R2 from 1.72 +/- 0.30 to 2.38 +/- 0.16 mm Hg x s x mL(-1), and C from 0.78 +/- 0.16 to 0.46 +/- 0.08 mL x mm Hg(-1). This altered VA coupling from 1.22 +/- 0.11 to 0.44 +/- 0.07. SW decreased from 4056 +/- 223 to 2372 +/- 122 mm Hg x mL, and PVA and SW/PVA decreased from 5575 +/- 514 to 4830 +/- 317 mm Hg x mL, and from 0.76 +/- 0.04 to 0.49 +/- 0.03, respectively. In group DOBU, dobutamine restored Ees and the position of ESPVR to baseline values, while Ea decreased to 3.39 +/- 0.34 mm Hg x mL(-1) because of an R2 decrease to 1.60 +/- 0.24 mm Hg x s x mL(-1). VA coupling was restored. SW and PVA increased to 3833 +/- 180 mm Hg x mL and to 7498 +/- 442 mm Hg x mL, respectively, while SW/PVA was unchanged. In ischemic pigs, dobutamine restored VA coupling through an increase in LV contractility and decrease in arterial elastance as a result of peripheral vasodilatation. However, myocardial oxygen consumption was increased, and mechanical efficiency impaired.
Original languageEnglish
Pages (from-to)144-52
Number of pages9
JournalJournal of cardiovascular pharmacology
Volume45
Issue number2
Publication statusPublished - Feb 2005

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Dobutamine
Swine
Pressure
Stroke
Blood Pressure
Stroke Volume
Coronary Occlusion
Left Ventricular Function
Vasodilation
Oxygen Consumption
Vascular Resistance
Compliance
Blood Vessels
Coronary Vessels

Keywords

  • Algorithms
  • Animals
  • Arteries
  • Blood Pressure
  • Blood Volume
  • Cardiotonic Agents
  • Dobutamine
  • Energy Metabolism
  • Female
  • Heart
  • Heart Rate
  • Heart Ventricles
  • Infusions, Intravenous
  • Male
  • Muscle Contraction
  • Muscle, Smooth, Vascular
  • Myocardial Contraction
  • Myocardial Ischemia
  • Swine
  • Vascular Resistance

Cite this

Kolh, P., Lambermont, B., Ghuysen, A., Tchana-Sato, V., Dogne, J-M., Hanson, J., ... Limet, R. (2005). Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs. Journal of cardiovascular pharmacology, 45(2), 144-52.
Kolh, Philippe ; Lambermont, Bernard ; Ghuysen, Alexandre ; Tchana-Sato, Vincent ; Dogne, Jean-Michel ; Hanson, Julien ; Gerard, Paul ; D'Orio, Vincent ; Pierard, Luc ; Limet, Raymond. / Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs. In: Journal of cardiovascular pharmacology. 2005 ; Vol. 45, No. 2. pp. 144-52.
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Kolh, P, Lambermont, B, Ghuysen, A, Tchana-Sato, V, Dogne, J-M, Hanson, J, Gerard, P, D'Orio, V, Pierard, L & Limet, R 2005, 'Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs', Journal of cardiovascular pharmacology, vol. 45, no. 2, pp. 144-52.

Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs. / Kolh, Philippe; Lambermont, Bernard; Ghuysen, Alexandre; Tchana-Sato, Vincent; Dogne, Jean-Michel; Hanson, Julien; Gerard, Paul; D'Orio, Vincent; Pierard, Luc; Limet, Raymond.

In: Journal of cardiovascular pharmacology, Vol. 45, No. 2, 02.2005, p. 144-52.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs

AU - Kolh, Philippe

AU - Lambermont, Bernard

AU - Ghuysen, Alexandre

AU - Tchana-Sato, Vincent

AU - Dogne, Jean-Michel

AU - Hanson, Julien

AU - Gerard, Paul

AU - D'Orio, Vincent

AU - Pierard, Luc

AU - Limet, Raymond

PY - 2005/2

Y1 - 2005/2

N2 - This study investigated the effects of dobutamine on left ventriculoarterial (VA) coupling and mechanical efficiency in acutely ischemic pigs. Experiments were performed in 12 pigs in which vascular properties, including peripheral resistance (R2), compliance (C), and arterial elastance (Ea), were estimated with a windkessel model, and left ventricular (LV) function by the slope (Ees) of the end-systolic pressure-volume relationship (ESPVR) and stroke work (SW). VA coupling was defined as Ees/Ea, and mechanical efficiency as SW/pressure-volume area (PVA). In all animals, the left anterior descending coronary artery was ligated after basal measures. The animals were then randomly divided into 2 groups: group CTRL (n = 6) was followed for 180 minutes without other intervention, whereas group DOBU (n = 6) was infused with dobutamine (5 microg x kg(-1) x min(-1)) starting after T60 measures. Coronary occlusion induced a rightward shift of ESPVR and a decrease in Ees from 3.67 +/- 0.33 to 1.92 +/- 0.20 mm Hg x mL(-1), while Ea changed from 3.33 +/- 0.56 to 4.65 +/- 0.29 mm Hg x mL, R2 from 1.72 +/- 0.30 to 2.38 +/- 0.16 mm Hg x s x mL(-1), and C from 0.78 +/- 0.16 to 0.46 +/- 0.08 mL x mm Hg(-1). This altered VA coupling from 1.22 +/- 0.11 to 0.44 +/- 0.07. SW decreased from 4056 +/- 223 to 2372 +/- 122 mm Hg x mL, and PVA and SW/PVA decreased from 5575 +/- 514 to 4830 +/- 317 mm Hg x mL, and from 0.76 +/- 0.04 to 0.49 +/- 0.03, respectively. In group DOBU, dobutamine restored Ees and the position of ESPVR to baseline values, while Ea decreased to 3.39 +/- 0.34 mm Hg x mL(-1) because of an R2 decrease to 1.60 +/- 0.24 mm Hg x s x mL(-1). VA coupling was restored. SW and PVA increased to 3833 +/- 180 mm Hg x mL and to 7498 +/- 442 mm Hg x mL, respectively, while SW/PVA was unchanged. In ischemic pigs, dobutamine restored VA coupling through an increase in LV contractility and decrease in arterial elastance as a result of peripheral vasodilatation. However, myocardial oxygen consumption was increased, and mechanical efficiency impaired.

AB - This study investigated the effects of dobutamine on left ventriculoarterial (VA) coupling and mechanical efficiency in acutely ischemic pigs. Experiments were performed in 12 pigs in which vascular properties, including peripheral resistance (R2), compliance (C), and arterial elastance (Ea), were estimated with a windkessel model, and left ventricular (LV) function by the slope (Ees) of the end-systolic pressure-volume relationship (ESPVR) and stroke work (SW). VA coupling was defined as Ees/Ea, and mechanical efficiency as SW/pressure-volume area (PVA). In all animals, the left anterior descending coronary artery was ligated after basal measures. The animals were then randomly divided into 2 groups: group CTRL (n = 6) was followed for 180 minutes without other intervention, whereas group DOBU (n = 6) was infused with dobutamine (5 microg x kg(-1) x min(-1)) starting after T60 measures. Coronary occlusion induced a rightward shift of ESPVR and a decrease in Ees from 3.67 +/- 0.33 to 1.92 +/- 0.20 mm Hg x mL(-1), while Ea changed from 3.33 +/- 0.56 to 4.65 +/- 0.29 mm Hg x mL, R2 from 1.72 +/- 0.30 to 2.38 +/- 0.16 mm Hg x s x mL(-1), and C from 0.78 +/- 0.16 to 0.46 +/- 0.08 mL x mm Hg(-1). This altered VA coupling from 1.22 +/- 0.11 to 0.44 +/- 0.07. SW decreased from 4056 +/- 223 to 2372 +/- 122 mm Hg x mL, and PVA and SW/PVA decreased from 5575 +/- 514 to 4830 +/- 317 mm Hg x mL, and from 0.76 +/- 0.04 to 0.49 +/- 0.03, respectively. In group DOBU, dobutamine restored Ees and the position of ESPVR to baseline values, while Ea decreased to 3.39 +/- 0.34 mm Hg x mL(-1) because of an R2 decrease to 1.60 +/- 0.24 mm Hg x s x mL(-1). VA coupling was restored. SW and PVA increased to 3833 +/- 180 mm Hg x mL and to 7498 +/- 442 mm Hg x mL, respectively, while SW/PVA was unchanged. In ischemic pigs, dobutamine restored VA coupling through an increase in LV contractility and decrease in arterial elastance as a result of peripheral vasodilatation. However, myocardial oxygen consumption was increased, and mechanical efficiency impaired.

KW - Algorithms

KW - Animals

KW - Arteries

KW - Blood Pressure

KW - Blood Volume

KW - Cardiotonic Agents

KW - Dobutamine

KW - Energy Metabolism

KW - Female

KW - Heart

KW - Heart Rate

KW - Heart Ventricles

KW - Infusions, Intravenous

KW - Male

KW - Muscle Contraction

KW - Muscle, Smooth, Vascular

KW - Myocardial Contraction

KW - Myocardial Ischemia

KW - Swine

KW - Vascular Resistance

M3 - Article

C2 - 15654263

VL - 45

SP - 144

EP - 152

JO - Journal of cardiovascular pharmacology

JF - Journal of cardiovascular pharmacology

SN - 0160-2446

IS - 2

ER -