Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Thi Kim Duy Vo, Patrice Godard, Marie de Saint-Hubert, Gabriel Morrhaye, Florence Debacq-Chainiaux, Christian Swine, Vincent Geenen, Henri J. Martens, Olivier Toussaint

Research output: Contribution to journalArticle

Abstract

The abundance of a selection of transcript species involved in inflammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2-4 after hospitalization) or convalescence phase (days 7-10) and 28 healthy aged controls. Twenty-nine differentially abundant transcripts were identified in acute phase versus healthy ageing. Twelve of these transcripts remained differentially abundant in convalescence phase, and 22 were similarly differentially abundant in acute phase of geriatric infectious diseases. Seven of these 22 transcripts were previously identified as differentially abundant in PBMC of healthy aged versus healthy young controls, with further alteration for CD28, CD69, LCK, CTSD, HMOX1, and TNFRSF1A in acute phase after geriatric hip fracture and infectious diseases. The next question is whether these alterations are common to other geriatric diseases and/or preexist before the clinical onset of the diseases. © 2010 Elsevier Inc.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalExperimental Gerontology
Volume46
Issue number4
DOIs
Publication statusPublished - 1 Apr 2011

    Fingerprint

Keywords

  • Ageing
  • Gene expression
  • Hip fracture
  • Immunosenescence
  • Inflammation
  • Oxidative stress
  • PBMC

Cite this