### Abstract

Original language | English |
---|---|

Pages (from-to) | H2295-301 |

Journal | American Journal of Physiology-Heart and Circulatory Physiology |

Volume | 284 |

Issue number | 6 |

DOIs | |

Publication status | Published - Jun 2003 |

### Fingerprint

### Keywords

- Animals
- Arteries
- Blood Pressure
- Cardiac Output
- Elasticity
- Energy Metabolism
- Female
- Heart Rate
- Hypertrophy, Left Ventricular
- Male
- Myocardial Contraction
- Stroke Volume
- Swine
- Vascular Resistance
- Ventricular Function, Left

### Cite this

*American Journal of Physiology-Heart and Circulatory Physiology*,

*284*(6), H2295-301. https://doi.org/10.1152/ajpheart.01110.2002

}

*American Journal of Physiology-Heart and Circulatory Physiology*, vol. 284, no. 6, pp. H2295-301. https://doi.org/10.1152/ajpheart.01110.2002

**Determinants of left ventricular preload-adjusted maximal power.** / Segers, Patrick; Tchana-Sato, Vincent; Leather, H Alex; Lambermont, Bernard; Ghuysen, Alexandre; Dogne, Jean-Michel; Benoit, Patricia; Morimont, Philippe; Wouters, Patrick F; Verdonck, Pascal; Kolh, Philippe.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Determinants of left ventricular preload-adjusted maximal power

AU - Segers, Patrick

AU - Tchana-Sato, Vincent

AU - Leather, H Alex

AU - Lambermont, Bernard

AU - Ghuysen, Alexandre

AU - Dogne, Jean-Michel

AU - Benoit, Patricia

AU - Morimont, Philippe

AU - Wouters, Patrick F

AU - Verdonck, Pascal

AU - Kolh, Philippe

PY - 2003/6

Y1 - 2003/6

N2 - Maximal left ventricular (LV) hydraulic power output (PWR(max)), corrected for preload as PWR(max)/(V(ed))(beta) (where V(ed) is the end-diastolic volume and beta is a constant coefficient), is an index of LV contractility. Whereas preload-adjusted maximal power (PAMP) is usually calculated with beta = 2, there is uncertainty about the optimal value of beta (beta = 1 for the normal LV and 2 for the dilated LV). The aim of this work is to study the determining factors of beta. The data set consisted of 245 recordings (steady state and vena cava occlusion) in 10 animals in an ischemic heart pig model. The occlusion data yielded the slope (E(es); 2.01 +/- 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V(0); -11.9 +/- 22.6 ml; range -76 to 39 ml) of the end-systolic pressure-volume relation, and the optimal beta-factor (assessed by fitting an exponential curve through the V(ed)-PWR(max) relation) was 1.94 +/- 0.88 (range 0.29-4.73). The relation of beta with V(ed) was weak [beta = 0.60 + 0.02(V(ed)); r(2) = 0.20]. In contrast, we found an excellent exponential relation between V(0) and beta [beta = 2.16e(0.0189(V(0))), r(2) = 0.70]. PAMP, calculated from the steady-state data, was 0.64 +/- 0.40 mW/ml(2) (range 0.14-2.83 mW/ml(2)) with a poor correlation with E(es) (r = 0.30, P

AB - Maximal left ventricular (LV) hydraulic power output (PWR(max)), corrected for preload as PWR(max)/(V(ed))(beta) (where V(ed) is the end-diastolic volume and beta is a constant coefficient), is an index of LV contractility. Whereas preload-adjusted maximal power (PAMP) is usually calculated with beta = 2, there is uncertainty about the optimal value of beta (beta = 1 for the normal LV and 2 for the dilated LV). The aim of this work is to study the determining factors of beta. The data set consisted of 245 recordings (steady state and vena cava occlusion) in 10 animals in an ischemic heart pig model. The occlusion data yielded the slope (E(es); 2.01 +/- 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V(0); -11.9 +/- 22.6 ml; range -76 to 39 ml) of the end-systolic pressure-volume relation, and the optimal beta-factor (assessed by fitting an exponential curve through the V(ed)-PWR(max) relation) was 1.94 +/- 0.88 (range 0.29-4.73). The relation of beta with V(ed) was weak [beta = 0.60 + 0.02(V(ed)); r(2) = 0.20]. In contrast, we found an excellent exponential relation between V(0) and beta [beta = 2.16e(0.0189(V(0))), r(2) = 0.70]. PAMP, calculated from the steady-state data, was 0.64 +/- 0.40 mW/ml(2) (range 0.14-2.83 mW/ml(2)) with a poor correlation with E(es) (r = 0.30, P

KW - Animals

KW - Arteries

KW - Blood Pressure

KW - Cardiac Output

KW - Elasticity

KW - Energy Metabolism

KW - Female

KW - Heart Rate

KW - Hypertrophy, Left Ventricular

KW - Male

KW - Myocardial Contraction

KW - Stroke Volume

KW - Swine

KW - Vascular Resistance

KW - Ventricular Function, Left

U2 - 10.1152/ajpheart.01110.2002

DO - 10.1152/ajpheart.01110.2002

M3 - Article

C2 - 12637350

VL - 284

SP - H2295-301

JO - American Journal of Physiology-Heart and Circulatory Physiology

JF - American Journal of Physiology-Heart and Circulatory Physiology

SN - 0363-6135

IS - 6

ER -