Keyphrases
1H-indole
43%
Crystalline Properties
40%
Tryptophan 2,3-dioxygenase (TDO2)
40%
Cancer Therapy
32%
Cancer Cells
26%
3-dioxygenase Inhibitor
23%
TDO Inhibitor
20%
Alkenyl
20%
Immunomodulator
20%
Chloro
20%
Electronic Properties
20%
Promising Target
20%
Thiosemicarbazone
20%
Orally Active
20%
Immune Resistance
20%
Tryptophan Depletion
16%
Cancer Tumor
16%
Immune Rejection
16%
Natural Immune System
16%
Enzymatic Mechanism
16%
Quinolinic Acid
16%
Immunosuppression
16%
Efficacy in Vivo
16%
Electrostatic Dipole
16%
Kynurenine Pathway
15%
Tryptophan
13%
T Cells
13%
Cancer Patients
13%
Coplanarity
13%
Tumor
13%
Cl Atoms
13%
Therapeutic Vaccination
13%
Posters
13%
Indoleamine 2,3-dioxygenase 1 (IDO1)
13%
Rapid Degradation
13%
Synthetic Inhibitors
10%
Molecular Electrostatic Potential
10%
Dipole Moment
10%
X Ray Diffraction
10%
Quantum Mechanics
10%
Inhibitory Activity
10%
Benzaldehyde Thiosemicarbazone
10%
Cell Test
10%
Electronic Characteristics
10%
Inhibitory Potential
6%
Humanized
6%
Ralstonia Eutropha
6%
Point Packing
6%
Single Crystal X-ray Analysis
6%
Subtle Change
6%
Nonplanar Structure
6%
Local Variation
6%
Steric Effect
6%
Oral Bioavailability
5%
Heterocyclic Compounds
5%
Tryptophan Catabolites
5%
Aromatic Moieties
5%
Antimicrobial
5%
Metal Chelates
5%
Imidazole
5%
Indazole
5%
Heteroaromatics
5%
Anxiety-like Behavior
5%
Immunomodulatory
5%
Ribonucleotides
5%
Genetic Impact
5%
Pharmacological Intervention
5%
Orally Bioavailable
5%
Amino Acid Catabolism
5%
Tryptophan Oxidation
5%
Metal Chelating Properties
5%
Preclinical in Vivo Models
5%
Pharmacological Profile
5%
Ribonucleotide Reductase
5%
Triapine
5%
INIS
tryptophan
100%
cancer
100%
indoles
86%
synthesis
70%
enzymes
43%
hydrogen 1
42%
isomers
40%
crystals
40%
tumors
36%
immunotherapy
32%
therapy
30%
design
20%
kynurenine
18%
in vivo
16%
immunosuppression
15%
patients
12%
grants
12%
lymphocytes
12%
resist
12%
proliferation
12%
liver
9%
catabolism
8%
aromatics
8%
solubility
7%
inhibition
7%
crystallography
7%
evaluation
6%
biological availability
5%
dipole moments
5%
quantum mechanics
5%
electrostatics
5%
crystal structure
5%
x-ray diffraction
5%
packings
5%
molecules
5%
Pharmacology, Toxicology and Pharmaceutical Science
Tryptophan 2,3 Dioxygenase
100%
Indole Derivative
63%
Malignant Neoplasm
51%
Immunomodulating Agent
40%
Tryptophan
34%
Immunotherapy
31%
Neoplasm
30%
Virtual Screening
20%
Thiosemicarbazone Derivative
20%
Indole
20%
Indoleamine 2,3 Dioxygenase
19%
Cupriavidus metallidurans
17%
Quinolinic Acid
14%
Kynurenine
14%
Immunosuppressive Agent
11%
Vaccination Policy
11%
Bond Length
10%
Molecular Target
10%
Heterocyclic Compound
5%
Indazole Derivative
5%
Imidazole
5%
Naphthalene
5%
Ribonucleotide
5%
Thiosemicarbazone
5%
Metisazone
5%
Ribonucleotide Reductase
5%
3 Aminopicolinaldehyde Thiosemicarbazone
5%
Antivirus Agent
5%
Antifungal Agent
5%