Study of model biosensors and soft lithography techniques by nonlinear optical chemical imaging: towards the development of fast decoding and label-free high-density biosensors arrays

Biosensors rely on the recognition of target molecules in aqueous solution by probe molecules adsorbed at a liquid-solid interface. Our project exploits the interfacial selectivity of 2nd order optical processes, the spatial resolution associated to the Sum Frequency (SF) beam short wavelength and the sensitivity of SF generation spectroscopy towards the biological recognition process. This study aims at developing new decoding and fabrications methods of highly packed and rapid biosensor arrays