Knee osteoarthritis is a disease characterized by a degradation of articular cartilage and synovial membrane inflammation that accelerates the degradation. This pathology has consequences on the whole joint, i.e. articular cartilage, menisci, synovial membrane, synovial fluid, ligaments and bones. One of the most common used treatment is the intraarticular injection of corticosteroids. Despite their massive use, the real effects of these drugs on the whole joint are not very well known. There is a need to perform studies allowing a better definition of corticosteroids effects. The goal of this master thesis was to study in vivo the effects of intra-articular injections of Triamcinolone hexacetonide on menisci and synovial fluid. A preliminary study was conducted to complement knowledge about the effects of ageing on menisci and synovial fluid to ensure that the corticosteroids effects observed thereafter were well due to the drugs and not to the age of the animals. The preliminary study did not show any significant correlation between age and the outcome measures (structure of menisci, hyaluronic acid content in the synovial fluid and matrix metalloproteinases activity in the synovial fluid). Intra-articular injections of Triamcinolone hexacetonide did not show any significant effects neither on the biochemical composition of menisci (water, proteoglycan and collagen contents) nor on the synovial fluid (hyaluronic acid content in the synovial fluid and matrix metalloproteinases activity in the synovial fluid)
| la date de réponse | 2016 |
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| langue originale | Anglais |
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| L'institution diplômante | |
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| Superviseur | Jean-Michel Vandeweerd (Promoteur) |
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Effects of corticosteroids on menisci and synovial fluid ? A study in an ovine model
Grisanti, G. (Auteur). 2016
Student thesis: Master types › Master en biochimie et biologie moléculaire et cellulaire